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Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid

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dc.contributor.author Mvango, Sindisiwe
dc.contributor.author Mthimkhulu, N
dc.contributor.author Fru, PA
dc.contributor.author Pilcher, LA
dc.contributor.author Balogun, Mohammed O
dc.date.accessioned 2021-02-15T10:25:43Z
dc.date.available 2021-02-15T10:25:43Z
dc.date.issued 2020-11
dc.identifier.citation Mvango, S., Mthimkhulu, N., Fru, P., Pilcher, L. & Balogun, M.O. 2020. Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid. http://hdl.handle.net/10204/11765 . en_ZA
dc.identifier.isbn 978-0-7354-4019-7
dc.identifier.uri http://hdl.handle.net/10204/11765
dc.description.abstract Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and bioavailability. Attempts have been made to improve the solubility of BA by conjugation to the water-soluble polymer polyethylene glycol (PEG) but with very limited physico-chemical characterizations. This work presents physico-chemical characterizations of a PEG-BA conjugate using 1H NMR spectroscopy, electron microscopy, DLS and XRD. The NMR data showed successful conjugation through the formation of an amide bond with a 5% drug loading although the appearance of some chemical shift signals were solvent-dependent. TEM images showed a spherical morphology of the conjugate with average diameter of 59.58±4.47 nm. en_US
dc.format Fulltext en_US
dc.language.iso en en_US
dc.relation.uri https://doi.org/10.1063/5.0028479 en_US
dc.relation.uri https://aip.scitation.org/doi/10.1063/5.0028479 en_US
dc.relation.uri https://aip.scitation.org/doi/pdf/10.1063/5.0028479 en_US
dc.source Proceedings of PPS2019 Europe-Africa Regional Conference of the Polymer Processing Society, AIP Conference Proceedings 2289, November 2020 en_US
dc.subject Betulinic acid en_US
dc.subject BA en_US
dc.title Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid en_US
dc.type Conference Presentation en_US
dc.description.pages 6 en_US
dc.description.note © 2020 Author(s). en_US
dc.description.cluster Chemicals
dc.description.impactarea Advanced Functional Materials en_US
dc.identifier.apacitation Mvango, S., Mthimkhulu, N., Fru, P., Pilcher, L., & Balogun, M. O. (2020). Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid. http://hdl.handle.net/10204/11765 en_ZA
dc.identifier.chicagocitation Mvango, Sindisiwe, N Mthimkhulu, PA Fru, LA Pilcher, and Mohammed O Balogun. "Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid." <i>Proceedings of PPS2019 Europe-Africa Regional Conference of the Polymer Processing Society, AIP Conference Proceedings 2289, November 2020</i> (2020): http://hdl.handle.net/10204/11765 en_ZA
dc.identifier.vancouvercitation Mvango S, Mthimkhulu N, Fru P, Pilcher L, Balogun MO, Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid; 2020. http://hdl.handle.net/10204/11765 . en_ZA
dc.identifier.ris TY - Conference Presentation AU - Mvango, Sindisiwe AU - Mthimkhulu, N AU - Fru, PA AU - Pilcher, LA AU - Balogun, Mohammed O AB - Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and bioavailability. Attempts have been made to improve the solubility of BA by conjugation to the water-soluble polymer polyethylene glycol (PEG) but with very limited physico-chemical characterizations. This work presents physico-chemical characterizations of a PEG-BA conjugate using 1H NMR spectroscopy, electron microscopy, DLS and XRD. The NMR data showed successful conjugation through the formation of an amide bond with a 5% drug loading although the appearance of some chemical shift signals were solvent-dependent. TEM images showed a spherical morphology of the conjugate with average diameter of 59.58±4.47 nm. DA - 2020-11 DB - ResearchSpace DP - CSIR J1 - Proceedings of PPS2019 Europe-Africa Regional Conference of the Polymer Processing Society, AIP Conference Proceedings 2289, November 2020 KW - Betulinic acid KW - BA LK - https://researchspace.csir.co.za PY - 2020 SM - 978-0-7354-4019-7 T1 - Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid TI - Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid UR - http://hdl.handle.net/10204/11765 ER - en_ZA
dc.identifier.worklist 24161 en_US


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