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Browsing Research Publications/Outputs by Cluster "Next Generation Health"

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Advances in CRISPR-Cas9 for the Baculovirus Vector System: A systematic review

Author: Sari-Ak, D ; Alomari, O ; Shomali, RA ; Lim, J ; Thimiri Govindaraj, Deepak B Date: Dec 2022 The baculovirus expression vector systems (BEVS) have been widely used for the recombinant production of proteins in insect cells and with high insert capacity. However, baculovirus does not replicate in mammalian cells; thus, the BacMam ... Read more
AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Author: Zodwa, Dlamini, Z ; Skepu, Amanda ; Kim, N ; Mkhabele, M ; Khanyile, R ; Molefi, T ; Mbatha, S ; Setlai, B ; Mulaudzi, T ; Mabongo, M Date: May 2022 Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic or proteomic information. ... Read more
Application of drug repurposing-based precision medicine platform for leukaemia patient treatment

Author: Kenmogne, Vanelle L ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PN ; Thimiri Govindaraj, Deepak B Date: Oct 2022 Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular ... Read more
Aptamer-Based Tumor-Targeted Diagnosis and Drug Delivery

Author: Woldekidan, Haregewoin B ; Woldesemayat, AA ; Adam, G ; Tafesse, Mesfin ; Thimiri Govindaraj, Deepak B Date: Jul 2022 Early cancer identification is crucial for providing patients with safe and timely therapy. Highly dependable and adaptive technologies will be required to detect the presence of biological markers for cancer at very low levels in the early ... Read more
Bioinformatics tools for gene and genome annotation analysis of microbes for synthetic biology and cancer biology applications

Author: Nweke, EE ; Suleman, Essa ; Du Plessis, M ; Thimiri Govindaraj, Deepak B Date: Aug 2021 In this book chapter, we focus on application of genome annotation and analysis of microbes for synthetic biology and cancer biology research. We particularly emphasised on application of microbial genomics in synthetic biology and cancer ... Read more
Boar seminal plasma proteomic profiling for biomarker discovery

Author: Mokwena, Pateswana W ; Stoychev, Stoyan H ; Buthelezi, Sindisiwe G ; Naicker, Previn ; Ramukhithi, FV ; Lehloenya, KC Date: Dec 2022 As an important technology in the swine industry, artificial insemination is of great significance in the preservation of elite breeds and the improvement of the utilisation rate of elite breeds, which makes the quality of preserved pig semen ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Candida parapsilosis cell wall proteome characterization and effectiveness against hematogenously disseminated candidiasis in a murine model

Author: Gong, X ; Srivastava, V ; Naicker, Previn ; Khan, A ; Ahmad, A Date: Mar 2023 Candida parapsilosis poses huge treatment challenges in the clinical settings of South Africa, and often causes infections among immunocompromised patients and underweight neonates. Cell wall proteins have been known to play vital roles in ... Read more
Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission

Author: Alexander, Kabamba ; Malatji, Kanyane ; Mulaudzi, Takalani Date: May 2020 Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased ... Read more
Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics

Author: Tumba, NL ; Naicker, Previn ; Stoychev, Stoyan H ; Killick, MA ; Owen, GR ; Papathanasopoulos, MA Date: Jul 2022 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ... Read more
CSIR Synthetic Biology and Precision Medicine Centre Bio-foundry Program

Author: Thimiri Govindaraj, Deepak B Date: Jan 2022 Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key role in the ... Read more
CSIR Synthetic Biology and Precision Medicine Centre Biofoundry Program: Development for first of its kind Biofoundry lab in Africa

Author: Thimiri Govindaraj, Deepak B Date: Mar 2023 Background: Global bio-foundry Alliance (GBA) has been established between countries including the UK, US, Japan, Singapore, China, Australia, Denmark, and Canada through 16 research institutions. Global bio-foundry Alliance plays the key ... Read more
Development of a multiplex HIV/TB diagnostic assay based on the microarray technology

Author: Malatji, Kanyane ; Singh, Advaita A ; Thobakgale, C ; Alexandre, Kabamba Date: Sep 2023 Currently there are diagnostic tests available for human immunodeficiency virus (HIV) and tuberculosis (TB); however, they are still diagnosed separately, which can delay treatment in cases of co-infection. Here we report on a multiplex ... Read more
Development of insect cell line using CRISPR technology

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 In this chapter, we delineated the methods of CRISPR technology that has been used for the development of engineered insect cell line. We elaborated on how CRISPR/Cas9 genome editing in Drosophila melanogaster, Bombyx mori, Spodoptera frugiperda ... Read more
Dose immunogenicity study of a plant-produced influenza virus-like particle vaccine in layer hens

Author: Abolnik, C ; Smith, Tanya ; Wandrag, BDR ; Murphy, M ; Rautenbach, M ; Olibile, O ; O'Kennedy, Maretha M Date: Jun 2022 Avian influenza poses one of the largest known threats to global poultry production and human health, but effective poultry vaccines can reduce infections rates, production losses and prevent mortalities, and reduce viral shed to limit further ... Read more
Drug sensitivity and drug repurposing platform for cancer precision medicine

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 One of the critical Global challenges in achieving the UN Sustainable Development Goals 3 Good Health and Well Being is optimizing drug discovery and translational research for unmet medical need in both communicable and non-communicable ... Read more
Efficacy of a plant-produced clade 2.3.4.4 H5 influenza virus-like particle vaccine in layer hens

Author: Abolnik, C ; O’Kennedy, Martha M ; Murphy, MA ; Wandrag, BDR Date: Jun 2022 Outbreaks caused by Goose/Guangdong H5 highly pathogenic avian influenza (HPAI)-lineage viruses continue to occur in unprecedented numbers throughout Eurasia, the Middle East and Africa, causing billions of dollars in economic losses and the ... Read more
Efficacy of a plant-produced clade 2.3.4.4 H5 influenza virus-like particle vaccine in layer hens

Author: Abolnik, C ; O'Kennedy, Martha M ; Murphy, MA ; Wandrag, DBR Date: Jun 2022 Outbreaks caused by Goose/Guangdong H5 highly pathogenic avian influenza (HPAI)-lineage viruses continue to occur in unprecedented numbers throughout Eurasia, the Middle East and Africa, causing billions of dollars in economic losses and the ... Read more
Efficacy of a plant-produced infectious bronchitis virus-like particle vaccine inspecific pathogen-free chickens

Author: Sepotokele, KM ; O’Kennedy, Martha M ; Hayes, MC ; Wandrag, DBR ; Smith, P ; Abolnik, C Date: Oct 2023 Infectious bronchitis (IB) Gammacoronavirus causes a highly contagious respiratory disease in chickens that is listed by the World Organisation for Animal Health (WOAH). Its high mutation ability has resulted in numerous variants against which ... Read more c b n d
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more

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