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Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses

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dc.contributor.author Dennis, SJ
dc.contributor.author O'Kennedy, Maretha M
dc.contributor.author Rutkowska, Daria A
dc.contributor.author Tsekoa, Tsepo L
dc.contributor.author Lourens, Carina W
dc.contributor.author Hitzeroth, II
dc.contributor.author Meyers, AE
dc.contributor.author Rybicki, EP
dc.date.accessioned 2019-01-29T08:01:30Z
dc.date.available 2019-01-29T08:01:30Z
dc.date.issued 2018-10
dc.identifier.citation Dennis, S.J. et al. 2018. Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. Veterinary Research, vol. 49: https://doi.org/10.1186/s13567-018-0600-4 en_US
dc.identifier.issn 1993-5412
dc.identifier.issn 1994-4659
dc.identifier.uri https://doi.org/10.1186/s13567-018-0600-4
dc.identifier.uri https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-018-0600-4
dc.identifier.uri http://hdl.handle.net/10204/10648
dc.description Open access article published in Veterinary Research, vol. 49: https://doi.org/10.1186/s13567-018-0600-4 en_US
dc.description.abstract African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries Worklist;21947
dc.subject African horse sickness en_US
dc.subject AHS en_US
dc.title Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses en_US
dc.type Article en_US
dc.identifier.apacitation Dennis, S., O'Kennedy, M. M., Rutkowska, D. A., Tsekoa, T. L., Lourens, C. W., Hitzeroth, I., ... Rybicki, E. (2018). Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. http://hdl.handle.net/10204/10648 en_ZA
dc.identifier.chicagocitation Dennis, SJ, Maretha M O'Kennedy, Daria A Rutkowska, Tsepo L Tsekoa, Carina W Lourens, II Hitzeroth, AE Meyers, and EP Rybicki "Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses." (2018) http://hdl.handle.net/10204/10648 en_ZA
dc.identifier.vancouvercitation Dennis S, O'Kennedy MM, Rutkowska DA, Tsekoa TL, Lourens CW, Hitzeroth I, et al. Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses. 2018; http://hdl.handle.net/10204/10648. en_ZA
dc.identifier.ris TY - Article AU - Dennis, SJ AU - O'Kennedy, Maretha M AU - Rutkowska, Daria A AU - Tsekoa, Tsepo L AU - Lourens, Carina W AU - Hitzeroth, II AU - Meyers, AE AU - Rybicki, EP AB - African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses. DA - 2018-10 DB - ResearchSpace DP - CSIR KW - African horse sickness KW - AHS LK - https://researchspace.csir.co.za PY - 2018 SM - 1993-5412 SM - 1994-4659 T1 - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses TI - Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses UR - http://hdl.handle.net/10204/10648 ER - en_ZA


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