dc.contributor.author |
Mangisa, M
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|
dc.contributor.author |
Tembu, VJ
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|
dc.contributor.author |
Fouché, Gerda
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|
dc.contributor.author |
Nthambeleni, Rudzani
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|
dc.contributor.author |
Peter, Xolani K
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|
dc.contributor.author |
Langat, MK
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|
dc.date.accessioned |
2018-09-18T07:46:35Z |
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dc.date.available |
2018-09-18T07:46:35Z |
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dc.date.issued |
2018-05 |
|
dc.identifier.citation |
Mangisa, M. et al. 2018. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. Natural Product Research, vol. 9: 1-8 |
en_US |
dc.identifier.issn |
1478-6419 |
|
dc.identifier.issn |
1478-6427 |
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dc.identifier.uri |
https://doi.org/10.1080/14786419.2018.1470628
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|
dc.identifier.uri |
https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1470628
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|
dc.identifier.uri |
http://hdl.handle.net/10204/10406
|
|
dc.description |
© 2018 Informa UK Limited, trading as Taylor & Francis Group. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. |
en_US |
dc.description.abstract |
The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and was found to be potent at low µg/mL ranges. Compound 1, 6a-acetoxy-14-ketoent-abieta-7(8),13(15)-diene-16,12-olide (mangiolide) inhibited the growth of renal (TK10) with a GI5(sub)50 of 0.02 µg/mL; a GI(sub)50 of 0.03 µg/mL for melanoma (UACC62) and a GI(sub)50 of 0.05 µg/mL for breast (MCF7) cancer cell lines. Compound 2, 8,13-diepoxy-13,15-ent-abietene-16,12-olide (jolkinolide B) inhibited the growth (GI(sub)50) of the cell lines at 3.31 µg/ mL for renal (TK10), 0.94 µg/mL for melanoma (UACC62) and 2.99 µg/ mL for the breast (MCF7). The structures were established on the basis of their spectroscopic analysis and the absolute stereostructures assigned using electronic circular dichroism (ECD). |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Taylor & Francis |
en_US |
dc.relation.ispartofseries |
Worklist;20948 |
|
dc.subject |
Cytotoxicity |
en_US |
dc.subject |
Cancer cell lines |
en_US |
dc.subject |
Ent-abietane diterpenoid lactone |
en_US |
dc.subject |
Suregada zanzibariensis |
en_US |
dc.subject |
Euphorbiaceae |
en_US |
dc.title |
Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties |
en_US |
dc.type |
Article |
en_US |
dc.identifier.apacitation |
Mangisa, M., Tembu, V., Fouché, G., Nthambeleni, R., Peter, X. K., & Langat, M. (2018). Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. http://hdl.handle.net/10204/10406 |
en_ZA |
dc.identifier.chicagocitation |
Mangisa, M, VJ Tembu, Gerda Fouché, Rudzani Nthambeleni, Xolani K Peter, and MK Langat "Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties." (2018) http://hdl.handle.net/10204/10406 |
en_ZA |
dc.identifier.vancouvercitation |
Mangisa M, Tembu V, Fouché G, Nthambeleni R, Peter XK, Langat M. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. 2018; http://hdl.handle.net/10204/10406. |
en_ZA |
dc.identifier.ris |
TY - Article
AU - Mangisa, M
AU - Tembu, VJ
AU - Fouché, Gerda
AU - Nthambeleni, Rudzani
AU - Peter, Xolani K
AU - Langat, MK
AB - The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and was found to be potent at low µg/mL ranges. Compound 1, 6a-acetoxy-14-ketoent-abieta-7(8),13(15)-diene-16,12-olide (mangiolide) inhibited the growth of renal (TK10) with a GI5(sub)50 of 0.02 µg/mL; a GI(sub)50 of 0.03 µg/mL for melanoma (UACC62) and a GI(sub)50 of 0.05 µg/mL for breast (MCF7) cancer cell lines. Compound 2, 8,13-diepoxy-13,15-ent-abietene-16,12-olide (jolkinolide B) inhibited the growth (GI(sub)50) of the cell lines at 3.31 µg/ mL for renal (TK10), 0.94 µg/mL for melanoma (UACC62) and 2.99 µg/ mL for the breast (MCF7). The structures were established on the basis of their spectroscopic analysis and the absolute stereostructures assigned using electronic circular dichroism (ECD).
DA - 2018-05
DB - ResearchSpace
DP - CSIR
KW - Cytotoxicity
KW - Cancer cell lines
KW - Ent-abietane diterpenoid lactone
KW - Suregada zanzibariensis
KW - Euphorbiaceae
LK - https://researchspace.csir.co.za
PY - 2018
SM - 1478-6419
SM - 1478-6427
T1 - Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties
TI - Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties
UR - http://hdl.handle.net/10204/10406
ER -
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en_ZA |