Browsing Biosciences by Author "Oldfield, LC"

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Heterologous expression of plasmodial proteins for structural studies and functional annotation

Birkholtz, LM; Blatch, G; Coetzer, TL; Hoppe, HC; Human, E; Morris, EJ; Ngcete, Z; Oldfield, LC; Roth, RL; Shonhai, A; Stephens, L; Louw, AI (BioMed Central, 2008)

Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of plasmodium parasites to the cost-effective chloroquine ...
The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

Kenyon, CP; Steyn, A; Roth, RL; Steenkamp, PA; Nkosi, TC; Oldfield, LC (BioMed Central, 2011-07)

Kinase and synthetase enzymes utilise C8D-ATP in preference to non-deuterated ATP. The KIE obtained at low ATP concentrations is clearly a primary KIE demonstrating strong evidence that the bond to the isotopically substituted ...

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