http://hdl.handle.net/10204/884 2013-06-20T00:58:04Z http://hdl.handle.net/10204/6683 Title: Evaluation of natural products as potential agrochemical agents with insecticide, fungicide and herbicide activities Authors: Dumontet, V; Litaudon, M; Olivon, F; Poullain, C; Rasoanaivo, C; Stien, D; Eparvier, V; Houël, E; Fokialakis, N; Halabalaki, M; Skaltsounis, AL; Espinosa, A; Olmedo, D; Gupta, M; Fouche, G; Hamburger, M; Sorgenfrei, O; Breuninger, D; Guéritte, F Abstract: The present work aims to identify new promising plant sources, which could be exploited for their agrochemical properties. A total of 484 natural products from academic libraries were selected for screening against four fungal pathogens, five insects and two plants. On the basis of the hits founded and a literature survey, the flora of source countries (New Caledonia, French Guiana, Madagascar, Panama, South Africa and Greece) was analysed for plants containing the desired scaffolds. Lists of 1800 plant part samples were thus established. The plant parts collected generated 3600 extracts that are being evaluated. Description: The International Congress on Natural Products Research, New York City, 28 July - 1 August 2012 2012-07-01T00:00:00Z http://hdl.handle.net/10204/6589 Title: Antioxidant, acetylcholinesterase inhibitory activity and cytotoxicity assessment of the crude extracts of Boophane disticha Authors: Adewusi, EA; Fouche, G; Steenkamp, V Abstract: Traditional healers use Boophane disticha to treat several neurodegenerative diseases. Further studies need to be carried out to justify its use in traditional medicine. Description: Copyright: 2012 African Journal of Pharmacology and Therapeutics, vol. 1(3), pp 78-83 2012-10-01T00:00:00Z http://hdl.handle.net/10204/6381 Title: Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae) Authors: Adekanmi, AE; Fouche, G; Steenkamp, V Abstract: Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients while bulb infusions are reported to be used to treat mental illness. The present study describes for the first time, the isolation of 6-hydroxycrinamine, a crinine alkaloid, from the methanol extract of the bulbs of Boophane disticha. Although this compound possessed activity, it was found to be toxic to the neuroblastoma cells. Quantitative structure-activity relationship studies could be carried out to modify the structure in order to make it less toxic and improve its activity. Description: Copyright: 2012 Elsevier. All rights reserved. This is the author’s version of the work. The definitive version is published in Journal of Ethnopharmacology, vol 143, issue 2, September 2012, pp 572-578, doi:10.1016/j.jep.2012.07.011. 2012-09-01T00:00:00Z http://hdl.handle.net/10204/6155 Title: An overview of the CSIR Health Research Impact Area Authors: Gardiner, D Abstract: In this presentation the author provides an overview of health R&D within the CSIR, and how the organisation is responding to challenges faced by the health care sector. Description: 4th Biennial CSIR Conference: Real problems relevant solutions, CSIR, Pretoria, 9-10 October 2012 2012-10-01T00:00:00Z