http://hdl.handle.net/10204/2517 2013-05-22T04:32:24Z 2013-05-22T04:32:24Z Msomi, N http://hdl.handle.net/10204/3248 2011-01-28T19:34:29Z 2008-11-17T00:00:00Z

Title: Impact of the national biotechnology strategy on the South African biopharma industry Authors: Msomi, N Abstract: The national biotechnology strategy was published in 2001. The process followed for drafting the strategy is as follows: involvement of experts; wider consultation with stakeholders and adoption and publication. The mandate for the BRICs was to focus on: commercialising biotechnology innovations coming out of universities, research councils, private sector; to focus on three focus areas of human health, bioprocessing, focus on animal health; plant biotechnology for PlantBio; to establish a national bioinformatics capacity to serve the biotechnology innovation needs (NBN) and to Build research-industry linkages Description: Science Real and Relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008

2008-11-17T00:00:00Z Kahari, D Koorsen, G Stoychev, S Chipeta, Z Labuschagne, M Van Zyl, P Nthangeni, B http://hdl.handle.net/10204/2866 2011-01-28T19:11:06Z 2008-11-01T00:00:00Z

Title: Glycoprofiling of N-linked glycans of erythropoietin therapeutic protein expressed in Yarrowia lipolytica Authors: Kahari, D; Koorsen, G; Stoychev, S; Chipeta, Z; Labuschagne, M; Van Zyl, P; Nthangeni, B Abstract: The CSIR Biosciences researchers are developing a platform for robust techniques for glyco-profiling of therapeutic glycoproteins. The extracellular lipase (Lip2) (Aloulou, A et al;2007) was used as a model in establishing and evaluating glycan profiling techniques. The gene encoding Lip2 was cloned as a C-terminally His-tagged protein, expressed in Yarrowia lipolytica (Madzak, C et al;2004) and the glycan composition of the purified protein was analysed by HPLC and MALDITOF. The HPLC techniques was also used to profile the glycan composition of EPO expressed in Yarrowia lipolytica yeast. Description: Science Real and Relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008

2008-11-01T00:00:00Z Becker, J Mtwisha, L Crampton, B Mancama, D http://hdl.handle.net/10204/2842 2011-01-28T19:07:10Z 2008-11-01T00:00:00Z

Title: Elucidating antimalarial drug targets/mode-of-action by application of system biology technologies Authors: Becker, J; Mtwisha, L; Crampton, B; Mancama, D Abstract: Malaria is one of the world's most important tropical diseases, killing more than a million of an estimated 300-500 million infected people per annum. The species responsible for the most fatalities amongst the genus is Plasmodium falsiparum. Eradication efforts are hampered by two major drawbacks-the absence of an effective vaccine coupled with the widespread occurrence of drug-resistant strains to frontline antimalarials and, of late, the emergence of resistance to current antimalarials of choice. In this regard, the researchers chose the polymine metabolic pathway in P. falciparum as a proof of concept project, to validate the pathway as a drug target and elucidate the (MoA) of cyclohexylamine in P. falciparum 3D7. Drug effects were examined through morphological characterisation of the parasite's life cycle, as well as transcriptomic and proteomic analyses. Description: Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008

2008-11-01T00:00:00Z Naidoo, K Rolfes, H Easton, K Moolman, FS Chetty, A Richter, PW Nilen, R Kotze, L http://hdl.handle.net/10204/2767 2011-01-28T19:33:49Z 2008-11-01T00:00:00Z

Title: Injection resorbable polymer shells for soft tissue augmentation Authors: Naidoo, K; Rolfes, H; Easton, K; Moolman, FS; Chetty, A; Richter, PW; Nilen, R; Kotze, L Abstract: CSIR researchers have developed an injectable, resorbable soft tissue bulking product that has potential applications in fields ranging from heart and recontructive surgery, to minimally invasive cosmetic surgery. Biomaterials research is very relevant to developing nations, especially due to the high injury-related burden of disease and defects due to insufficient pre-natal care amongst the poor and disadvantaged. This research focuses on producing a locally-manufactured resorbable biopolymeric particle system for use in soft tissue augmentation. This research has resulted in a patent application that has received a positive international preliminary report on patentability that will facilitate the eventual commercialisation of this unique product. Description: Science Real and Relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008

2008-11-01T00:00:00Z