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Browsing by Author "Wiid, I"

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Anti-mycobacterial peroxides: A new class of agents for development against tuberculosis

Author: Van der Westhuyzen, Christiaan W ; Haynes, J ; Panayides, Jenny-Lee ; Wiid, I ; Parkinson, C Date: 2020 Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like ... Read more
Design, synthesis, and in vitro antituberculosis activity of 2(5H)-Furanone derivatives

Author: Ngwane, AH ; Panayides, Jenny-Lee ; Chouteau, F ; Macingwana, L ; Viljoen, A ; Baker, B ; Madikane, E ; De Kock, C ; Wiesner, L ; Chibale, K ; Parkinson, CJ ; Mmutlane, EM ; Van Helden, P ; Wiid, I Date: Jan 2016 A series of 2(5H)-furanone-based compounds were synthesized from commercially available mucohalic acids. From the first-generation compounds, three showed inhibitory activity (10 µg/mL) of at least 35% against Mycobacterium smegmatis mc(2) ... Read more
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Author: Theron, Anjo ; Roth, Robyn L ; Hoppe, H ; Parkinson, C ; Van der Westhuyzen, Christiaan W ; Stoychev, Stoyan H ; Wiid, I ; Pietersen, RD ; Baker, B ; Kenyon, CP Date: Oct 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase. It is considered a ... Read more

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Browsing by Author "Wiid, I"

Browsing by Author "Wiid, I"

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