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Browsing by Subject "Pharmaceuticals"

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Chemical sensor nanotechnology in pharmaceutical drug research

Author: Thobakgale, Setumo L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Aug 2022 The increase in demand for pharmaceutical treatments due to pandemic-related illnesses has created a need for improved quality control in drug manufacturing. Understanding the physical, biological, and chemical properties of APIs is an important ... Read more
Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid

Author: Adeleke, Oluwatoyin A ; Karry, KM ; Michniak-Kohn, BB ; Monama, Nkwe O Date: Oct 2015 The purpose of this abstract is to design and characterize a thermodynamically stable mouth-dissolving film containing isoniazid employing in silico and in vitro techniques. Isoniazid (solubility = 140 mg/mL and log P = -0.64 at 25°C) is a ... Read more
Effect of expressing an anti-HIV lectin, Griffithsin, in different plant cellular compartments

Author: Stark, T ; Chakauya, E ; Kabamba, A ; Morris, L ; Rybicki, E ; Chikwamba, Rachel K Date: Aug 2010 Sub-Saharan Africa remains the region most heavily affected by HIV, and the majority of new infections from heterosexual contact are in women. Griffithsin (GRFT), a lectin isolated from the red algae Griffithsia, has shown extreme potency ... Read more
Effect of subcellular targeting on the expression and accumulation of Griffithsin in N. benthamiana

Author: Stark, T ; Chakauya, E ; Kabamba, A ; Morris, L ; Rybicki, E ; Chikwamba, Rachel K Date: 01 Sep 2010 Due to the increasing demand for pharmaceuticals and the high cost of production in traditional fermentor systems, plants are being considered as alternative production platforms for therapeutic molecules. One of the considerations for ... Read more
Impact of the national biotechnology strategy on the South African biopharma industry

Author: Msomi, N Date: 17 Nov 2008 The national biotechnology strategy was published in 2001. The process followed for drafting the strategy is as follows: involvement of experts; wider consultation with stakeholders and adoption and publication. The mandate for the BRICs was ... Read more
Inorganic layered double hydroxides as a 4-hexyl resorcinol delivery system for topical applications

Author: Mosangi, Damodar ; Kesavan Pillai, Sreejarani ; Moyo, Lumbidzani ; Ray, Suprakas S Date: Aug 2016 In this study, the hydrophobic even skin tone active, 4-hexylresorcinol (HR), was intercalated into a zinc aluminium layered double hydroxide (ZnAl-LDH) by a co-precipitation method and used as a controlled release ingredient in skin care ... Read more c b
Novel platforms for essential biomolecules: expression of antibodies in plants

Author: Chikwamba, Rachel K ; Lotter, T ; Ramesaar, K Date: 28 Feb 2006 The demand for health products such as protein therapeutics and sub-unit vaccines to control infectious diseases far outweighs the current global production capacity of these molecules. These products are currently being produced in conventional ... Read more
Polymer-based protein delivery systems for loco-regional administration

Author: Garcion, E ; Ramalapa, Bathabile ; Buchtova, N ; Toullec, C ; Aucamp, M ; Le Bideau, J ; Hindré, F ; Dube, A ; Alvarez-Lorenzo, C ; Mansor, MH Date: Mar 2021 With the advent of recombinant technology, a wide variety of biocompatible therapeutic proteins can be produced with relative ease. These proteins are formulated and subsequently administered in patients to treat various of diseases in a ... Read more
Recent progress in the structural modification of chitosan for applications in diversified biomedical fields

Author: Mittal, Hemant ; Ray, Suprakas S ; Kaith, BS ; Bhatia, JK ; Sukriti ; Sharma, J ; Alhassan, SM Date: Dec 2018 This article critically reviews the recent developments in the structural modifications of chitosan and its nano-structured variants produced via different techniques and their potential applications in diversified biomedical fields such as ... Read more

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Browsing by Subject "Pharmaceuticals"

Browsing by Subject "Pharmaceuticals"

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