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Browsing by Author "Oldfield, LC"

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Heterologous expression of plasmodial proteins for structural studies and functional annotation

Author: Birkholtz, LM ; Blatch, G ; Coetzer, TL ; Hoppe, HC ; Human, E ; Morris, EJ ; Ngcete, Z ; Oldfield, LC ; Roth, Robyn L ; Shonhai, A ; Stephens, L ; Louw, AI Date: 2008 Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of plasmodium parasites to the cost-effective chloroquine and antifolates has ... Read more
The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

Author: Kenyon, CP ; Steyn, A ; Roth, Robyn L ; Steenkamp, PA ; Nkosi, TC ; Oldfield, LC Date: Jul 2011 Kinase and synthetase enzymes utilise C8D-ATP in preference to non-deuterated ATP. The KIE obtained at low ATP concentrations is clearly a primary KIE demonstrating strong evidence that the bond to the isotopically substituted hydrogen is ... Read more

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Browsing by Author "Oldfield, LC"

Browsing by Author "Oldfield, LC"

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