Author:Steenkamp, Lucia H; Brady, DDate:Jun 2010The non-steroidal anti-inflammatory drug naproxen is most effective as the single S-naproxen enantiomer. However, typical synthetic routes to naproxen yield the racemate of both the R and the S stereoisomers. Biocatalysts can be used to resolve ...Read more
Author:Steenkamp, Lucia H; Brady, DDate:Nov 2008The presentation starts with a comparison between Naproxen and Aspirin. The characteristics and properties of Naproxen are explained, as well as the biocatalysis and the screening of the enzyme activity and selectivity. It ends with a discussion ...Read more
Author:Steenkamp, Lucia H; Brady, DDate:03 Mar 2003This study focused on the identification of suitable lipase or esterase activity for enantiomeric resolution of (R, S)-naproxen. For an economically viable reaction the enantiomeric ratio (E) should preferably be >100, while maximising the ...Read more