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Browsing by Author "Naicker, B"

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Curdlan-conjugated PLGA nanoparticles possess macrophage stimulant activity and drug delivery capabilities

Author: Tukulula, M ; Hayeshi, R ; Fonteh, P ; Meyer, D ; Ndamase, A ; Madziva, MT ; Khumalo, V ; Lubuschagne, P ; Naicker, B ; Swai, H ; Dube, A Date: Feb 2015 There is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells. We hypothesized that curdlan (immune stimulating polymer) could be conjugated to PLGA and nanoparticles from this copolymer would ... Read more
Micronization, characterization and in-vitro dissolution of shellac from PGSS supercritical CO2 technique

Author: Labuschagne, Philip W ; Naicker, B ; Kalombo, Lonji Date: Feb 2016 The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution (PGSS) process and ... Read more
Permeation of PLGA nanoparticles across different in vitro models

Author: Nkabinde, LA ; Shoba-Zikhali, LN ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, HS ; Hayeshi, R ; Naicker, B ; Hillie, TK ; Hamman, JH Date: Jul 2012 Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake ... Read more
Preliminary formulation and characterization of solid lipid nanoparticles containing chloroquine and a P-glycoprotein inhibitor: Influences of lipid-surfactant ratios

Author: Nzekwe, IT ; Azodo, VI ; Agubata, CO ; Naicker, B ; Okore, V ; Esimone, CO Date: Feb 2015 Chloroquine, a once useful therapy, currently faces problems of plasmodial resistance mediated through a number of mechanisms, such as P-glycoprotein (P-gp) mediated drug efflux, which makes attainment of adequate drug levels impossible. In ... Read more

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Browsing by Author "Naicker, B"

Browsing by Author "Naicker, B"

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