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Browsing by Author "Moleele, SS"

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Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

Author: Bode, ML ; Gravestock, D ; Moleele, SS ; Van der Westhuyzen, Christiaan W ; Pelly, SC ; Steenkamp, PA ; Hoppe, HC ; Khan, T ; Nkabinde, LA Date: Jun 2011 During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the ... Read more
Pyrimidines in antimalarial drug design

Author: Moleele, SS ; Gravestock, D ; Rousseau, AL ; Van Zyl, RL Date: Sep 2008 Malaria causes the death of 2-3 million people annually, most of these children under 5 years of age. Approximately 300 million cases of acute malaria are reported each year, 90% of these in Africa. Until recently, folate metabolism has been ... Read more

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Browsing by Author "Moleele, SS"

Browsing by Author "Moleele, SS"

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