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Browsing by Author "Michniak-Kohn, BB"

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Combined atomistic molecular calculations and experimental investigations for the architecture, screening, optimization, and characterization of pyrazinamide containing oral film formulations for tuberculosis management

Author: Adeleke, Oluwatoyin A ; Monama, Nkwe O ; Tsai, PC ; Sithole, Happy M ; Michniak-Kohn, BB Date: Dec 2015 To date, effective treatment, prophylaxis, and control of tuberculosis (TB) infection is mainly dependent on the use of drugs. However, patient noncompliance with prescribed anti-TB treatment schemes remains a major problem confronting ... Read more
Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid

Author: Adeleke, Oluwatoyin A ; Karry, KM ; Michniak-Kohn, BB ; Monama, Nkwe O Date: Oct 2015 The purpose of this abstract is to design and characterize a thermodynamically stable mouth-dissolving film containing isoniazid employing in silico and in vitro techniques. Isoniazid (solubility = 140 mg/mL and log P = -0.64 at 25°C) is a ... Read more
Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization

Author: Adeleke, Oluwatoyin A ; Tsai, P ; Karry, KM ; Monama, Nkwe O ; Michniak-Kohn, BB Date: Aug 2021 Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing ... Read more
Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide

Author: Adeleke, Oluwatoyin A ; Tsai, P-C ; Michniak-Kohn, BB Date: Oct 2015 The purpose of this research is to prepare, characterize as well as assess the ex vivo buccal drug delivery and cytotoxicity of an orally disintegrating film (ODF) loaded with pyrazinamide. Pyrazinamide (solubility = 15 mg/mL at 25°C; log P ... Read more

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Browsing by Author "Michniak-Kohn, BB"

Browsing by Author "Michniak-Kohn, BB"

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