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Browsing by Author "Manoto, Sello L"

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Biocongugation of gold nanoparticles for surface plasmon resonance sensor

Author: Manoto, Sello L ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Over the past few years gold nanoparticle (AuNPs) have become extremely interesting because they possess enhanced optical, electrical and chemical properties. AuNPs have the ability to form robust conjugates with biomolecules such as antibodies ... Read more
Characterisation of a Bessel beam optical cell sorting system using microspheres

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2020 Accurate sorting of specific particles in a mixed population is a desirable capability in the field of biomedical sciences. This enables researchers to purify samples by selecting only the particles of interest. Optical sorting is achieved ... Read more
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jun 2020 Human immunodeficiency virus (HIV) infection remains a global health challenge despite the use of antiretroviral therapy, which has led to a significant decline in the mortality rates. Owing to the unavailability of an effective treatment to ... Read more
Could low level laser therapy and highly active antiretroviral therapy lead to complete eradication of HIV-1 in vitro?

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine or a ... Read more
Design and FDTD simulation of photonic crystal based sensor for biosensing applications

Author: Manoto, Sello L ; Mabena, Chemist M ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Photonic crystals (PhCs) is a unique and flexible class of optical devices that are able to manipulate the electromagnetic fields of light. PhCs is a subwavelength grating structure with a periodic arrangement of a high refractive index layer ... Read more
Detection of biological analytes using surface plasmon resonance as a biosensing technique for possible development of a point of care diagnostic tool

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, Malik ; Mthunzi-Kufa, Patience Date: Feb 2019 Surface Plasmon Resonance (SPR) is a very powerful optical sensing technique that detects bimolecular binding interactions and it has turned out to be a suitable platform for clinical analysis. In biological and chemical sensing applications, ... Read more
Detection of mycobacterium tuberculosis using gold nanoparticles conjugated to TB antibodies

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2021 In recent years, conjugated nanoparticles have gained significant applications in diagnostics, particularly gold nanoparticles (AuNPs). When functionalized with antibodies, AuNPs can selectively interact with cells and biomolecules. The ... Read more
Development of collinear transmission plasmonic biosensor for detection of HIV-1

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Mthunzi-Kufa, Patience Date: Feb 2020 Surface Plasmon Resonance (SPR) which is widely used to study interactions between different types of biomolecules, has emerged as a technique of choice for rapid and quantitative analyses. However, there are still some challenges on the use ... Read more
Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis?

Author: Manoto, Sello L Date: Jan 2020 Osteoarthritis is a degenerative joint disease that is difficult to manage and a major cause of disability in the elderly population. The use of ozone for treatment of knee osteoarthritis (KOA) is controversial and of interest. Although the ... Read more
The effects of low level laser therapy on both HIV-1 infected and uninfected TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and ... Read more
Efficient femtosecond driven SOX 17 delivery into mouse embryonic stem cells: Differentiation study

Author: Thobakgale, Setumo L ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Embryonic stem cells have great promise in regenerative medicine because of their ability to self-renew and differentiate into various cell types. Delivery of therapeutic genes into cells has already been achieved using of chemical agents and ... Read more
Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles

Author: Oluwole, DA ; Manoto, Sello L ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience ; Nyokong, T Date: Mar 2018 We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical ... Read more
Examining HIV infected cells using optical trapping and Raman spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Sep 2021 Manipulation of biological cells using optical trapping is a non-invasive approach in which individual living cells are examined without causing any damage because there is no direct mechanical contact with cells. Optical trapping uses a ... Read more
Examining HIV infected cells using optical trapping and Raman spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Sep 2021 Manipulation of biological cells using optical trapping is a non-invasive approach in which individual living cells are examined without causing any damage because there is no direct mechanical contact with cells. Optical trapping uses a ... Read more
Exploring optical spectroscopic techniques and nanomaterials for virus detection

Author: Manoto, Sello L ; El-Hussein, A ; Malabi, Rudzani ; Thobakgale, Setumo L ; Ombinda-Lemboumba, Saturnin ; Attia, YA ; Kasem, MA ; Mthunzi-Kufa, Patience Date: Aug 2020 Viral infections pose significant health challenges globally by affecting millions of people worldwide and consequently resulting in a negative impact on both socioeconomic development and health. Corona virus disease 2019 (COVID-19) is a ... Read more
Femtosecond laser assisted photo-transfection and differentiation of mouse embryonic stem cells

Author: Thobakgale, Setumo L ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2018 In tissue engineering research, stem cells have been used as starting material in the synthesis of mammalian cells for the treatment of various cell based diseases. This is done by manipulating the DNA content of the cells to induce a specific ... Read more
Gelatine-based biosensor for molecular screening of aspirin and paracetamol via surface enhanced Raman spectroscopy

Author: Thobakgale, Setumo L ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Feb 2020 Polypeptide gelatine has been used extensively in microbiology to enhance cellular adhesion and growth. Likewise, fabrication of biochemical sensors using a variety of organic material and nanomaterials is a growing research area particularly ... Read more
Growth and characterisation of gold thin film layer using an ebeam evaporation system for surface plasmon resonance applications

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Khanyile, S ; Khamlich, S ; Maaza, M ; Mthunzi-Kufa, Patience Date: Apr 2019 Gold thin metal layers have been seen to be the most important signal amplification components in electrochemical and optical sensor applications. In surface plasmon resonance (SPR) applications, gold thin metal film possess electron densities ... Read more
In-vitro photo-translocation of antiretroviral drug delivery into TZMbl cells

Author: Malabi, Rudzani ; Manoto, Sello L ; Maaza, M ; Mthunzi-Kufa, Patience ; Ombinda-Lemboumba, Saturnin Date: Jan 2017 The objectives of this study are to use femtosecond laser pulses in a photo-translocation system to deliver ARVs into HIV infected TZMbl cells, and to investigate the influence of ARVs and laser on cellular processes using different molecular ... Read more
In-vitro photo-translocation of antiretroviral drug delivery into TZMbl cells

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 The current human immunodeficiency virus (HIV) treatment regime possesses the ability to diminish the viral capacity to unnoticeable levels; however complete eradication of the virus cannot be achieved while latent HIV-1 reservoirs go ... Read more

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