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Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site

Author: Alexandre, Kabamba B ; Gray, ES ; Pantophlet, R ; Moore, PL ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Sep 2011 The glycans on HIV-1 gp120 play an important role in shielding neutralization sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study we investigated the interaction ... Read more
Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission

Author: Alexander, Kabamba ; Malatji, Kanyane ; Mulaudzi, Takalani Date: May 2020 Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased ... Read more
Effect of expressing an anti-HIV lectin, Griffithsin, in different plant cellular compartments

Author: Stark, T ; Chakauya, E ; Kabamba, A ; Morris, L ; Rybicki, E ; Chikwamba, Rachel K Date: Aug 2010 Sub-Saharan Africa remains the region most heavily affected by HIV, and the majority of new infections from heterosexual contact are in women. Griffithsin (GRFT), a lectin isolated from the red algae Griffithsia, has shown extreme potency ... Read more
Effect of subcellular targeting on the expression and accumulation of Griffithsin in N. benthamiana

Author: Stark, T ; Chakauya, E ; Kabamba, A ; Morris, L ; Rybicki, E ; Chikwamba, Rachel K Date: 01 Sep 2010 Due to the increasing demand for pharmaceuticals and the high cost of production in traditional fermentor systems, plants are being considered as alternative production platforms for therapeutic molecules. One of the considerations for ... Read more
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

Author: Alexandre, Kabamba B ; Gray, ES ; Mufhandu, Hazel T ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Feb 2012 It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) ... Read more
Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

Author: Alexandre, Kabamba B ; Moore, PL ; Nonyane, M ; Gray, ES ; Ranchobe, N ; Chakauya, E ; McMahon, JB ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Nov 2013 We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 strains cultured ... Read more

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Browsing by Subject "Griffithsin"

Browsing by Subject "Griffithsin"

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