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Browsing by Author "Fouché, Gerda"

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Acute and subacute toxicological evaluation of the aerial extract of Monsonia angustifolia E. Mey. ex. A. Rich in Wistar rats

Author: Afolayan, AJ ; Wintola, OA ; Fouché, Gerda Date: 2016 The acute and subacute toxicity profile of the aerial extract of Monsonia angustifolia in Wistar rats was evaluated. The Organization for Economic Cooperation and Development (OECD) 420 guideline was adopted in the acute toxicity testing with ... Read more
Agro-processing opportunities identified through a novel mosquito repellent from a medicinal plant

Author: Maharaj, VJ ; Fouché, Gerda ; Senabe, J ; Nthambeleni, R ; Kotze, F Date: Nov 2008 Traditional healers provide CSIR scientists with indigenous knowledge (IK) that stimulates research and can eventually lead to discovery and development of new herbal remedies. The rights of these providers of IK, to share in future benefits ... Read more
Anthelmintic activity of acetone extracts from South African plants used on egg hatching of Haemonchus contortus

Author: Sakong, BM ; Adenubi, OT ; Pauw, E ; Eloff, JN ; Fouché, Gerda ; Leboho, Tlabo ; Wellington, Kevin W Date: 2016 The nematode, Haemonchus contortus, is responsible for major economic losses in the livestock industry. The management of parasites such as H. contortus has been through the use of synthetic parasiticides. This has resulted in the presence ... Read more
Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)

Author: Mokoka, TA ; Peter, Xolani K ; Fouché, Gerda ; Moodley, N ; Adams, M ; Hamburger, M ; Kaiser, M ; Brun, R ; Maharaj, V ; Koorbanally, Nicoli A Date: Jan 2014 In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, ... Read more
Antioxidant, acetylcholinesterase inhibitory activity and cytotoxicity assessment of the crude extracts of Boophane disticha

Author: Adewusi, EA ; Fouché, Gerda ; Steenkamp, V Date: Oct 2012 Traditional healers use Boophane disticha to treat several neurodegenerative diseases. Further studies need to be carried out to justify its use in traditional medicine. Read more
Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus

Author: Hata, Y ; Raith, M ; Ebrahimi, SN ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj, V ; Kaiser, M ; Brun, R ; Hamburger, M Date: Apr 2013 A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovani. A CH(sub)2Cl(sub)2/MeOH (1:1) extract ... Read more
Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II

Author: Mokoka, TA ; Peter, Xolani K ; Zimmermann, S ; Hata, Y ; Adams, M ; Kaiser, M ; Moodley, N ; Maharaj, V ; Koorbanally, Nicoli A ; Hamburger, M ; Brun, B ; Fouché, Gerda Date: Aug 2013 Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts ... Read more
Antitrypanosomal isoflavan quinones from Abrus precatorius

Author: Hata, Y ; Ebrahimi, SN ; De Mieri, M ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj ; Kaiser, M ; Brun, R ; Potterat, O ; Hamburger, M Date: Mar 2014 Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus ... Read more
Bakers yeast-mediated transformations of alpha-keto epoxides

Author: Meth-Cohn, O ; Horak, RM ; Fouché, Gerda Date: 07 Jun 1994 Alpha beta-Epoxy ketones on treatment with baker's yeast yield different types of products depending on their substitution. Small groups such as H or Me attached at the epoxy end protect that end from attack. Thus, 1-acyl epoxides with H, ... Read more
Chemical profiling with cytokine stimulating investigations of Sutherlandia frutescens L.R. (Br.) (Fabaceae)

Author: Faleschini, MT ; Myer, MS ; Harding, N ; Fouché, Gerda Date: Mar 2013 Sutherlandia frutescens, one of the medicinal plants of southern Africa, has been widely used to boost the immune system by various ethnic groups. This study aims to provide scientific evidence for in vitro immune modulating activities of ... Read more
Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects

Author: Gonyela, Odwa ; Peter, Xolani K ; Dewar, JB ; Van der Westhuysen, Christiaan W ; Steenkamp, Paul ; Fouché, Gerda Date: Aug 2019 A novel cycloartanol (1) and an acylated Sutherlandioside D (2) together with two known cycloartane derivatives, Sutherlandioside B (3) and Sutherlandioside A (4), were isolated from the aerial parts of Sutherlandia frutescens. The structures ... Read more
Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)

Author: Adekanmi, AE ; Fouché, Gerda ; Steenkamp, V Date: Sep 2012 Boophane disticha of the family Amaryllidaceae is used traditionally by the indigenous people of southern Africa in the treatment of several neurological disorders. Weak decoctions of bulb scales are given to sedate violent, psychotic patients ... Read more
Effect of four medicinal plants on amyloid-beta induced neurotoxicity in SH-SY5Y Cells

Author: Adewusi, EA ; Fouché, Gerda ; Steenkamp, V Date: 2013 Amyloid-beta peptide (Aß) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder. This study was designed to determine the effect of four medicinal plants used to treat neurodegenerative diseases on ... Read more
Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties

Author: Mangisa, M ; Tembu, VJ ; Fouché, Gerda ; Nthambeleni, Rudzani ; Peter, Xolani K ; Langat, MK Date: May 2018 The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH ... Read more
Evaluation of natural products as potential agrochemical agents with insecticide, fungicide and herbicide activities

Author: Dumontet, V ; Litaudon, M ; Olivon, F ; Poullain, C ; Rasoanaivo, C ; Stien, D ; Eparvier, V ; Houël, E ; Fokialakis, N ; Halabalaki, M ; Skaltsounis, AL ; Espinosa, A ; Olmedo, D ; Gupta, M ; Fouché, Gerda ; Hamburger, M ; Sorgenfrei, O ; Breuninger, D ; Guéritte, F Date: Jul 2012 The present work aims to identify new promising plant sources, which could be exploited for their agrochemical properties. A total of 484 natural products from academic libraries were selected for screening against four fungal pathogens, five ... Read more
Evaluation of South African plants with acaricide activity against ticks

Author: Fouché, Gerda ; Eloff, JN ; Wellington, Kevin W Date: 2017 Acaricides are commonly used to control ticks but are toxic, harmful to the environment and too expensive to resource-limited farmers. Traditionally, many communities in South Africa rely on a wide range of indigenous practices to keep their ... Read more
Further studies on South African plants: Acaricidal activity of organic plant extracts against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)

Author: Wellington, Kevin W ; Leboho, T ; Sakong, BM ; Adenubi, OT ; Eloff, JN ; Fouché, Gerda Date: Jan 2017 The goal of our research is to develop a lower cost eco-friendly tick control method because acaricides that are commonly used to control ticks are often toxic, harmful to the environment or too expensive for resource-limited farmers. Acetone ... Read more
High throughput screening of South African plants for anti-cancer properties

Author: Fouché, Gerda ; Senabe, J ; Khorombi, E ; Kolesnikoya, N ; Maharaj, VJ ; Nthambeleni, R Date: Nov 2008 Plants have a long history of use in the treatment of cancer and over 60% of currently used anti-cancer agents are derived in one way or another from natural sources. South Africa has a rich plant biodiversity with only a limited number ... Read more
Identification and isolation of compounds from Sutherlandia frutescens

Author: Faleschini, T ; Fouché, Gerda ; Harding, N ; Myer, M ; Dewar, J Date: 01 Sep 2010 Plants constitute the basic food chain and provide the most valuable source of natural nutrients; in addition, constituents of medicinal importance are also present in plants. For drug discovery and other purposes, we must characterise the ... Read more
In vitro anticancer screening of South African plants

Author: Fouché, Gerda ; Cragg, GM ; Pillay, P ; Kolesnikova, NI ; Maharaj, VJ ; Senabe, JV Date: Oct 2008 A total of 7500 plant extracts were screened for in vitro anticancer activity against a panel of three human cell lines (breast MCF7, renal TK10 and melanoma UACC62). Extracts were classified into four categories based on their total growth ... Read more

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