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Browsing by Author "Fanucchi, Stephanie"

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Chromosomal contact permits transcription between coregulated genes

Author: Fanucchi, Stephanie ; Shibayama, Y ; Burd, S ; Weinberg, MS ; Mhlanga, Musa Date: Oct 2013 Transcription of coregulated genes occurs in the context of long-range chromosomal contacts that form multigene complexes. Such contacts and transcription are lost in knockout studies of transcription factors and structural chromatin proteins. ... Read more
Discovering new host-directed therapies to treat inflammation

Author: Fanucchi, Stephanie Date: Aug 2017 Dr Fanucchi is a South African born cell biologist who was recently awarded the 2017 L'Oreal/UNESCO International Rising Talent Award (15 of which are awarded worldwide annually); she was also a finalist for the 2016/2017 TW Kambule-NSTF Award ... Read more
The emerging molecular biology toolbox for the study of long noncoding RNA biology

Author: Fok, Ezio T ; Scholefield, Janine ; Fanucchi, Stephanie ; Mhlanga, Musa Date: Oct 2017 Long noncoding RNAs (lncRNAs) have been implicated in many biological processes. However, due to the unique nature of lncRNAs and the consequential difficulties associated with their characterization, there is a growing disparity between the ... Read more
Enhancer-derived lncRNAs regulate genome architecture: fact or fiction?

Author: Fanucchi, Stephanie ; Mhlanga, Musa Date: Jun 2017 How does the non-coding portion of the genome contribute to the regulation of genome architecture? A recent paper by Tan et al. focuses on the relationship between cis-acting complex-trait-associated lincRNAs and the formation of chromosomal ... Read more
The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2

Author: Morris, G ; Stoychev, Stoyan H ; Naicker, Previn ; Dirr, HW ; Fanucchi, Stephanie Date: Jul 2018 Forkhead box (FOX) proteins are a ubiquitously expressed family of transcription factors that regulate the development and differentiation of a wide range of tissues in animals. The FOXP subfamily members are the only known FOX proteins capable ... Read more
lncRNA and gene looping: what’s the connection?

Author: Shibayama, Y ; Fanucchi, Stephanie ; Magagula, L ; Mhlanga, Musa Date: May 2014 Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the ... Read more
Visualization of enhancer-derived noncoding RNA

Author: Shibayama, Y ; Fanucchi, Stephanie ; Mhlanga, Musa Date: 2017 Enhancers are principal regulators that allow spatiotemporal tissue-specifi c control of gene expression. While mounting evidence suggests that enhancer-derived long noncoding RNAs (long ncRNAs), including enhancer RNAs (eRNAs), are an important ... Read more

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Browsing by Author "Fanucchi, Stephanie"

Browsing by Author "Fanucchi, Stephanie"

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