Author:Yeates, CA; Smit, MS; Botes, AL; Breytenbach, JC; Krieg, HMDate:Jan 2007Various studies have described the optimisation of the hydrolysis of epoxides through epoxide hydrolase, however, far fewer have investigated the specific application of whole cells containing the enzyme. For this reason the enantioselective ...Read more
Author:Brady, D; Steenkamp, Lucia H; Skein, E; Chaplin, JA; Reddy, SDate:04 Mar 2004In a biocatalytic reaction the immobilized lipase ChiroCLEC-CR enantioselectively hydrolysed a naproxen ethyl ester racemate, yielding (S)-naproxen with an enantiomeric excess of more than 98%, an enantiomeric ratio (E) of more than 100, and ...Read more
Author:Steenkamp, Lucia H; Brady, DDate:03 Mar 2003This study focused on the identification of suitable lipase or esterase activity for enantiomeric resolution of (R, S)-naproxen. For an economically viable reaction the enantiomeric ratio (E) should preferably be >100, while maximising the ...Read more