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Browsing by Subject "Anti-malarial drug resistance"

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Establishing malaria parasite transfection technology in South Africa

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, HC Date: Jan 2010 The most important contributing factor to the current malaria crisis is the rapid spread of parasite resistance to available anti-malarial drugs. Anti-malarial drug resistance is critical and the need for compounds with novel modes of action ... Read more
Establishing malaria parasite transfection technology in South Africa.

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, H Date: Jan 2010 In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ... Read more
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Author: Becker, JVW ; Van der Merwe, MM ; Van Brummelen, AC ; Pillay, P ; Crampton, BG ; Mmutlane, EM ; Parkinson, C ; Van Heerden, FR ; Crouch, NR ; Smith, PJ ; Mancama, Dalubuhle T ; Maharaj, VJ Date: Oct 2011 Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial ... Read more

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Browsing by Subject "Anti-malarial drug resistance"

Browsing by Subject "Anti-malarial drug resistance"

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