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Browsing by Subject "5-methyluridine"

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Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine

Author: Visser, Daniel F ; Gordon, GER ; Bode, ML ; Mathiba, K ; Brady, D Date: May 2012 5-Methyluridine (5-MU) is an intermediate in the synthesis of ß-thymidine and the antiretroviral drugs stavudine (d4T) and zidovudine (AZT)1-3. The enzymatic preparation of 5-MU involves transglycosylation4-6 and avoids the formation of ... Read more
Stabilization of Escherichia coli uridine phosphorylase by evolution and immobilization

Author: Visser, Daniel F ; Hennessy F ; Rashamuse J ; Pletschke B ; Brady D Date: Aug 2010 Uridine phosphorylase from Escherichia coli was evolved by iterative saturation mutagenesis. The best mutant showed a temperature optimum of 60C and a half-life of 17.3 h at 60C. The mutant enzyme, as well as a purine nucleoside phosphorylase ... Read more

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Browsing by Subject "5-methyluridine"

Browsing by Subject "5-methyluridine"

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