Author:Tumba, NL; Naicker, Previn; Stoychev, Stoyan H; Killick, MA; Owen, GR; Papathanasopoulos, MADate:Jul 2022The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ...Read more
Author:Owen, GR; Stoychev, Stoyan H; Achilonu, I; Dirr, HWDate:Oct 2014Many studies have characterized how changes to the stability and internal motions of a protein during activation can contribute to their catalytic function, even when structural changes cannot be observed. Here, unfolding studies and ...Read more
Author:Owen, GR; Le, D; Stoychev, Stoyan H; Cerutti, NM; Papathanasopoulos, MDate:Mar 2018CD4, a membrane glycoprotein expressed by specific leukocytes, plays a vital role in the human immune response and acts as a primary receptor for HIV entry. Of its four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide ...Read more