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Browsing by Subject "Plasmodium falciparum"

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Antimalarial properties of South African medicinal plants

Author: Pillay, P ; Maharaj, VJ ; Clarkson, C ; Chibale, K Date: Jan 2007 Malaria is the leading cause of death and disease worldwide. The evolution and spread of drug-resistant forms of the causative agent Plasmodium falciparum and the limited number of chemotherapeutic agents available to treat and control the ... Read more
Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II

Author: Mokoka, TA ; Peter, Xolani K ; Zimmermann, S ; Hata, Y ; Adams, M ; Kaiser, M ; Moodley, N ; Maharaj, V ; Koorbanally, Nicoli A ; Hamburger, M ; Brun, B ; Fouché, Gerda Date: Aug 2013 Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts ... Read more
Characterization, modelling and docking studies of Plasmodium falciparum kinase PfCDPK4

Author: Makungo, T ; Tsekoa, Tsepo L ; Theron, Anjo ; Mancama, Dalubuhle T ; Van Ree, T Date: Apr 2019 Characterization, modelling and docking studies of Plasmodium falciparum kinase PfCDPK4: The increasing incidence of Plasmodium strains that are resistant to current frontline antimalarial drugs has become one of the greatest challenges of ... Read more
Characterization, modelling and docking studies of Plasmodium falciparum kinase PfCDPK4

Author: Makungo, T ; Tsekoa, Tsepo L ; Theron, Anjo ; Mancama, Dalubuhle T ; Van Ree, T Date: Apr 2019 Characterization, modelling and docking studies of Plasmodium falciparum kinase PfCDPK4: The increasing incidence of Plasmodium strains that are resistant to current frontline antimalarial drugs has become one of the greatest challenges of ... Read more
Establishing malaria parasite transfection technology in South Africa

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, HC Date: Jan 2010 The most important contributing factor to the current malaria crisis is the rapid spread of parasite resistance to available anti-malarial drugs. Anti-malarial drug resistance is critical and the need for compounds with novel modes of action ... Read more
Establishing malaria parasite transfection technology in South Africa.

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, H Date: Jan 2010 In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ... Read more
In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Author: Clarkson, C ; Maharaj, VJ ; Crouch, NR ; Grace, WM ; Pillay, P ; Matsabisa, MG ; Bhagwandin, N ; Smith, PJ ; Folb, PI Date: Jun 2004 The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of ... Read more
Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome

Author: Becker, J ; Mtwisha, L ; Crampton, BG ; Stoychev, Stoyan H ; Van Brummelen, A ; Louw, A ; Birkholtz, L ; Mancama, Dalubuhle T Date: Mar 2009 Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. ... Read more
Molecular modelling of calcium dependent protein kinase 4 (CDPK4) from Plasmodium falciparum

Author: Tsekoa, Tsepo L Date: Oct 2009 Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ... Read more
New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic acid derivatives

Author: Reader, J ; Opperman, DFL ; Van der Watt, ME ; Theron, Anjo ; Leshabane, M ; Da Rocha, S ; Turner, J ; Garrabrant, K ; Piña, I ; Mills, C Date: Sep 2022 Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block human-to-mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium falciparum seem to be highly ... Read more
Optimization of an in vitro system to study the exo-erythrocytic stage of the human malaria parasite, Plasmodium falciparum

Author: Rossouw, C ; Chetty, A ; Moolman, S ; Hoppe, H ; Birkholtz, L ; Mancama, Dalubuhle T Date: Feb 2010 Much research remains to be done in order to understand the Plasmodium-liver interaction process. While previous in vitro studies have focused on two-dimensional (2D) cell culture, it is becoming more evident to researchers that the context ... Read more
PfPI3K, a Phosphatidylinsoitol-3 kinase in Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

Author: Vaid, A ; Ranjan, R ; Verma, G ; Smythe, WA ; Hoppe, HC ; Sharma, P Date: Mar 2010 phosphorylated phosphoinositides (PIPs) are potent second messengers, which trigger a wide variety of signaling and trafficking events in most eukaryotic cells. However, the role and metabolism of PIPs in malaria parasite Plasmodium have ... Read more
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

Author: Becker, JVW ; Mtwisha, L ; Crampton, BG ; Stoychev, Stoyan H ; Van Brummelen, AC ; Reeksting, S ; Louw, AI ; Birkholtz, LM ; Mancama, Dalubuhle T Date: Jan 2010 This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine ... Read more
Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines

Author: Aderibigbe, BA ; Neuse, EW ; Sadiku, ER ; Shina Ray, S ; Smith, PJ Date: 2014 In this research, aminoquinoline compounds were synthesized, characterized and incorporated into water soluble polymers to form conjugates. The conjugates were characterized by X ray Diffraction (XRD), Thermal Gravimetric Analysis (TGA), ... Read more

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Browsing by Subject "Plasmodium falciparum"

Browsing by Subject "Plasmodium falciparum"

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