Author:Chhiba, Varsha P; Bode, M; Mathiba, K; Kwezi, Lusisizwe; Brady, DDate:Apr 2012A range of ß-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These compounds were hydrolysed ...Read more
Author:Chhiba, Varsha P; Bode, M; Mathiba, K; Brady, DDate:Jun 2014The use of enzymes for the enantioselective synthesis of single enantiomer ß-subsituted compounds is of interest, as this structural motif occurs commonly in compounds of pharmaceutical importance, such as adrenergic agents, antidiabetics, ...Read more
Author:Mashweu, AR; Bode, ML; Brady, D; Chhiba, Varsha PDate:2020The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ...Read more