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Browsing by Subject "Microbicides"

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Evaluation of 5P12-RANTES analogue expression in Nicotiana benthamiana

Author: Mawela, KG Date: 10 Oct 2012 This presentation explains the role of 5P12-RANTES and its low-cost production as a promising topical microbicide. Read more
Expression of affordable microbicides to combat the spread of HIV pandemic

Author: Mawela, K ; Lezar, S ; Chakauya, E ; Eloff, JN ; Chikwamba, Rachel K Date: 01 Sep 2010 HIV prevalence is over 33 million worldwide with 68% of AIDS sufferers residing in sub-Saharan Africa (1). Currently the available HIV prevention tools are feasible but women cannot insist on these preventive measures due to social, cultural ... Read more
Inhibition of HIV-1 by a natural compound

Author: Van den Berg, N ; Mbobela, P ; Pillay, P ; Maharaj, V ; Khati, M Date: Jun 2011 CSIR Biosciences investigated the anti-HIV properties of a plant indigenous to the Eastern Cape, commonly used by traditional healers. A natural compound isolated from the plant, coded BP36, inhibited infectivity of HIV-1 pseudoviruses. The ... Read more
Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

Author: Alexandre, Kabamba B ; Moore, PL ; Nonyane, M ; Gray, ES ; Ranchobe, N ; Chakauya, E ; McMahon, JB ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Nov 2013 We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 strains cultured ... Read more
A natural microbicide (BP36) against HIV-1

Author: Maharaj, V Date: Oct 2012 In this presentation the author outlines the steps taken in developing a South African indigenous plant-based microbicide to prevent HIV infection in women. Read more
Plant made anti-HIV microbicides: a field of opportunity

Author: Lotter-Stark, HCT ; Rybick, EP ; Chikwamba, Rachel K Date: Nov 2012 HIV remains a global burden and without an effective vaccine, it is crucial to develop microbicides to halt the initial transmission of the virus. Several microbicides have been researched with various levels of success. Amongst these ... Read more
Progress and perspectives on HIV-1 microbicide development

Author: Alexandre, Kabamba B ; Mufhandu, Hazel T ; London, GM ; Chakauya, E ; Khati, M Date: Oct 2016 The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender ... Read more

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Browsing by Subject "Microbicides"

Browsing by Subject "Microbicides"

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