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UCT943, a next-generation plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of Malaria

Author: Brunschwig, C ; Lawrence, N ; Taylor, D ; Abay, E ; Njoroge, M ; Basarab, GS ; Le Manach, C ; Paquet, T ; Cabrera, DG ; Mancama, Dalubuhle T Date: Sep 2018 The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, ... Read more

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Browsing by Subject "Human dose prediction"

Browsing by Subject "Human dose prediction"

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