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An integrated chemo-enzymatic route for preparation of ß-thymidine, a key intermediate in the preparation of antiretrovirals

Author: Gordon, GER ; Bode, ML ; Visser, Daniel F ; Lepuru, MJ ; Zeevaart, JG ; Ragubeer, N ; Ratsaka, M ; Walwyn, DR ; Brady, D Date: Jan 2011 A chemo-enzymatic method for production of ß-thymidine, an intermediate in the synthesis of antiretrovirals, is described. Guanosine and thymine were converted by means of enzymatic transglycosylation to yield 5-methyluridine (5-MU), which ... Read more

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Browsing by Subject "Chemo-enzymatic"

Browsing by Subject "Chemo-enzymatic"

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