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Browsing by Subject "Sesquiterpene lactones"

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Antimalarial sesquiterpene lactones from oncosiphon piluliferum

Author: Pillay, P ; Maharaj, V ; Crouch, N ; Smith, P ; Lategan, C ; Vleggaar, R Date: Feb 2006 With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal ... Read more
Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II

Author: Mokoka, TA ; Peter, Xolani K ; Zimmermann, S ; Hata, Y ; Adams, M ; Kaiser, M ; Moodley, N ; Maharaj, V ; Koorbanally, Nicoli A ; Hamburger, M ; Brun, B ; Fouché, Gerda Date: Aug 2013 Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts ... Read more
Ethnomedicinal and phytochemical properties of sesquiterpene lactones from Dicoma (Asteraceae) and their anticancer pharmacological activities: A review

Author: Mangisa, Mandisa ; Peter, Xolani K ; Khosa, Mbokota ; Fouche, Gerda ; Nthambeleni, Rudzani ; Senabe, Jeremiah V ; Tarirai, C ; Tembu, VJ Date: Sep 2021 Dicoma species belonging to the Asteraceae family are commonly utilized as traditional medicine in Southern Africa. Dicoma anomala, Dicoma capensis, Dicoma schinzii and Dicoma zheyeri are the most common ethnomedicinal plant species used in ... Read more
Investigating South African plants as a source of new antimalarial drugs

Author: Pillay, P ; Maharaj, VJ ; Smith, PJ Date: Oct 2008 Based on the historical success of natural products as antimalarial drugs and the urgent need for new antimalarials, a number of South African medicinal plants have been evaluated for their antimalarial properties. This paper reviews the major ... Read more
Isolation and identification of antiplasmodial sesquiterpene lactones from Oncosiphon piluliferum

Author: Pillay, P ; Vleggaar, R ; Maharaj, VJ ; Smith, PJ ; Lategan, CA Date: May 2007 Oncosiphon piluliferum (Asteraceae) is used traditionally to treat a variety of ailments, mainly fevers. This prompted the screening of this plant for antiplasmodial properties. The dichloromethane extract of the aerial parts of the plant ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu, U ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more

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Browsing by Subject "Sesquiterpene lactones"

Browsing by Subject "Sesquiterpene lactones"

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