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Decision making in the development of a biocatalytic route for resolution of S-naproxen: from screening to scale-up

Author: Steenkamp, Lucia H ; Brady, D Date: Jun 2010 The non-steroidal anti-inflammatory drug naproxen is most effective as the single S-naproxen enantiomer. However, typical synthetic routes to naproxen yield the racemate of both the R and the S stereoisomers. Biocatalysts can be used to resolve ... Read more
Optimisation of stabilised carboxylesterase NP for enantioselective hydrolysis of naproxen methyl ester

Author: Steenkamp, Lucia H ; Brady, D Date: Dec 2008 Although the enantioselective kinetic resolution of ester racemates of the non-steroidal antiinflammatory drug naproxen ([2-(6-methoxy-2-naphthyl) propionic acid]) is a common demonstration for biocatalysis, the enantiomeric excess of the ... Read more

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Browsing by Subject "S-naproxen"

Browsing by Subject "S-naproxen"

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