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Browsing by Subject "Protein dynamics"

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Covalent binding of human two-domain CD4 to an HIV-1 subtype C SOSIP.664 trimer modulates its structural dynamics

Author: Tumba, NL ; Naicker, Previn ; Stoychev, Stoyan H ; Killick, MA ; Owen, GR ; Papathanasopoulos, MA Date: Jul 2022 The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) mediates host cell infection by binding to the cellular receptor CD4. Recombinant Env bound to CD4 has been explored for its potential as an HIV vaccine immunogen as ... Read more
Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1ß1 provide insight into its mechanisms of activation

Author: Owen, GR ; Stoychev, Stoyan H ; Achilonu, I ; Dirr, HW Date: Oct 2014 Many studies have characterized how changes to the stability and internal motions of a protein during activation can contribute to their catalytic function, even when structural changes cannot be observed. Here, unfolding studies and ... Read more
Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control

Author: Owen, GR ; Le, D ; Stoychev, Stoyan H ; Cerutti, NM ; Papathanasopoulos, M Date: Mar 2018 CD4, a membrane glycoprotein expressed by specific leukocytes, plays a vital role in the human immune response and acts as a primary receptor for HIV entry. Of its four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide ... Read more

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Browsing by Subject "Protein dynamics"

Browsing by Subject "Protein dynamics"

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