Author:Ndhundhuma, IMDate:Jan 2010Lasers have emerged as powerful tools for tissue engineering. To examine cellular growth, and cell to cell interactions, in vitro skin models have been developed combining two major cell types of skin, keratinocytes and fibroblasts. The main ...Read more
Author:Van Kets, V; Karsten, A; Davids, LDate:Sep 2010Photodynamic therapy (PDT) has recently emerged as a treatment modality for photorejuvenation of the skin. This study is a preliminary investigation into the effect of different light sources to activate hypericin, a plant-derived photosensitizer ...Read more
Author:Maduray, K; Karsten, A; Odhav, B; Nyokong, TDate:Sep 2010This preliminary photodynamic therapy study investigated the effect of different diode laser powers (mW) for the activation of two photosensitizers (AlTSPc, aluminum tetrasulfonatedphthalocyanine and ZnTSPc, zinc tetrasulfonatedphthalocyanine) ...Read more
Author:Ndhundhuma, IM; Falzone, N; Dam, JSDate:Aug 2008Photodynamic therapy (PDT) can be defined as the combination of a light sensitive drug known as a photosensitizer and visible light of specific wavelength. PDT is carried out by administration of photosensitizer either systemically, locally, ...Read more
Author:Karsten, AEDate:Oct 2008The wide spread use of lasers as a treatment modality emphasized the need that users are aware of the parameters that effect the dose applied during treatment. The results presented show the importance to know the optical parameters (absorption, ...Read more
Author:Ombinda-Lemboumba, Saturnin; du Plessis, A; Botha, LR; Rohwer, EG; Steenkanp, CMDate:01 Sep 2010Phthalocyanines are new class of photosensitiser used for photodynamic therapy. These drugs are used to treat small and superficial tumours. In recent years, a particular attention has been given to phthalocyanine in order to search suitable ...Read more
Author:Maduray, K; Karsten, A; Odhav, B; Nyokong, TDate:May 2011A series of water-soluble tetrasulfonated metallophthalocyanines (MPcs) dyes have been studied to be used as a drug or photosensitizer (PS) in photodynamic therapy (PDT) for the treatment of cancers. During PDT the PS is administrated ...Read more
Author:Maduray, K; Karsten, AEDate:Jan 2010Photodynamic therapy (PDT) uses a drug termed a photosensitizer (PS), light (laser) of an appropriate wavelength and molecular oxygen (tissue) to elicit cell death of cancer cells. The objective of this study was to evaluate the enhancement ...Read more
Author:Maduray, K; Karsten, A; Odhav, B; Nyokong, TDate:Jun 2010Aluminium and zinc tetrasulfophthalocyanines were activated with a 672nm wavelength laser to investigate the photodynamic effects on melanoma cancer, dermal fibroblast and epidermal keratinocyte cells. Aluminium tetrasulfophthalocyanine was ...Read more
Author:Maduray, K; Karsten, A; Odhav, B; Nyokong, TDate:Jun 2010Photodynamic therapy (PDT) represents a novel treatment that uses a photosensitizer (PS), light source (laser) of an appropriate wavelength and oxygen to induce cell death in cancer cells. The aim of this study was to investigate the photodynamic ...Read more
Author:Ndhundhuma, I; Hauser, C; Scalfi-Happ, C; Rück, A; Steiner, RDate:Aug 2011The exposure of a photosensitizer to visible light, preferably laser light in the red region, in the presence of molecular oxygen results in a photochemical reaction described as photodynamic therapy (PDT). Photodynamic therapy is increasingly ...Read more
Author:Nombona, N; Maduray, K; Antunes, E; Karsten, A; Nyokong, TDate:Feb 2012The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular ...Read more
Author:Ombinda-Lemboumba, Saturnin; du Plessis, A; Botha, LR; Rohwer, EG; Steenkamp, CMDate:Oct 2010The ultrafast dynamics of Zinc Phthalocyanine was studied using trasient absorption pump probe spectroscopy. Zinc Phthalocyanine was excited (pumped) at 672nm and probed by a white light continuum. The pump-probe technique used in this study ...Read more
Author:Karsten, AEDate:Nov 2008For effective laser treatment it is very important to provide the correct dose at the required treatment depth. In South Africa we have a richness of ethnic groups contributing to a large variety in skin tones. Effective laser treatment of ...Read more