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Browsing by Subject "Phosphoryl transfer"

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Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

Author: Kenyon, CP ; Roth, Robyn L ; Van der Westhuyzen, Christiaan W ; Parkinson, CJ Date: Mar 2012 The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that ... Read more
The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases

Author: Kenyon, CP ; Steyn, A ; Roth, Robyn L ; Steenkamp, PA ; Nkosi, TC ; Oldfield, LC Date: Jul 2011 Kinase and synthetase enzymes utilise C8D-ATP in preference to non-deuterated ATP. The KIE obtained at low ATP concentrations is clearly a primary KIE demonstrating strong evidence that the bond to the isotopically substituted hydrogen is ... Read more

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Browsing by Subject "Phosphoryl transfer"

Browsing by Subject "Phosphoryl transfer"

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