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Detection of antimycolic acid antibodies by liposomal biosensors

Author: Lemmer, Yolandy ; Thanyani, ST ; Vrey, PJ ; Driver, CHS ; Venter, L ; Van Wyngaardt, S ; Ten Bokum, AMC ; Ozoemena, KI ; Pilcher, LA ; Fernig, DG ; Stoltz, AC ; Swai, HS ; Verschoor, JA Date: 2009 Antibodies to mycolic acid (MA) antigens can be detected as surrogate markers of active tuberculosis (TB) with evanescent field biosensors where the lipid antigens are encapsulated in liposomes. Standard immunoassay such as ELISA, where the ... Read more
Detection of mycobacterium tuberculosis using gold nanoparticles conjugated to TB antibodies

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2021 In recent years, conjugated nanoparticles have gained significant applications in diagnostics, particularly gold nanoparticles (AuNPs). When functionalized with antibodies, AuNPs can selectively interact with cells and biomolecules. The ... Read more
Electron transfer dynamics across self-assembled N-(2-mercaptoethyl) octadecanamide/mycolic acid layers: impedimetric insights into the structural integrity and interaction with anti-mycolic acid antibodies

Author: Ozoemena, KI ; Mathebula, NS ; Pillay, J ; Toschi, G ; Verschoor, JA Date: 2010 The integrity and properties of mycolic acid (MA) antigens integrated into a self-assembled monolayer (SAM) of N-(2-mercaptoethyl)octadecanamide, (MEODA), on a gold electrode have been interrogated using cyclic voltammetry (CV) and electrochemical ... Read more
Optical biosensing of mycobacterium tuberculosis for point-of-care diagnosis

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Hlekelele, Lerato ; Mthunzi-Kufa, Patience Date: Feb 2020 An optical biosensor is a compact analytical device formed by a bio-recognition sensing element integrated to an optical transducer system which translates a signal into a readable outcome that is measured by the detector. The target analyte ... Read more
Providing an address for delivery of nanoencapsulated TB drugs

Author: Lemmer, Yolandy Date: Jun 2010 South Africa currently has the highest incidence of TB per 100 000 people in the world. In 2007 alone 112 000 people died of TB in South Africa, of which 94 000 were co-infected with HIV (1). Although TB treatments exist, poor patient treatment ... Read more
Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

Author: Mathebula, NS ; Pillay, J ; Toschi, G ; Verschoor, JA ; Ozoemena, KI Date: 2009 Electrochemical impedimetric recognition by anti-mycolic acid antibodies, present in tuberculosis (TB)-positive human serum co-infected with human immunodeficiency virus (HIV), of mycolic acids (MA) integrated into a self-assembled monolayer ... Read more
Surface plasmon resonance (SPR) based biosensor for mycobacterium tuberculosis diagnosis

Author: Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Mar 2021 Recently, various nanomaterials have been used to develop nanotechnology-based rapid diagnostic tests. Due to their unique optical properties, gold nanoparticles (AuNPs) have been employed to design and develop modern biosensors for the rapid ... Read more

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Browsing by Subject "Mycolic acid"

Browsing by Subject "Mycolic acid"

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