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Browsing by Subject "Mycobacterium tuberculosis"

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Anti-mycobacterial peroxides: A new class of agents for development against tuberculosis

Author: Van der Westhuyzen, Christiaan W ; Haynes, J ; Panayides, Jenny-Lee ; Wiid, I ; Parkinson, C Date: 2020 Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like ... Read more
The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies

Author: Ranchod, Heena ; Ndlandla, Fortunate L ; Lemmer, Yolandy ; Beukes, M ; Niebuhr, J ; Al-Dulayymi, J Date: Aug 2018 Mycolic acids (MA) are major, species-specific lipid components of Mycobacteria and related genera. In Mycobacterium tuberculosis, it is made up of alpha-, methoxy- and keto-MA, each with specific biological functions and conformational ... Read more
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Author: Theron, Anjo ; Roth, Robyn L ; Hoppe, H ; Parkinson, C ; Van der Westhuyzen, Christiaan W ; Stoychev, Stoyan H ; Wiid, I ; Pietersen, RD ; Baker, B ; Kenyon, CP Date: Oct 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase. It is considered a ... Read more
Exploring the bioactivity of pentacyclic triterpenoids as potential antimycobacterial nutraceutics: Insights through comparative biomolecular modelling

Author: Tolufashe, FF ; Lawal, MM ; Govender, Krishna K ; Shode, FO ; Singh, T Date: Mar 2021 A group of bioactive compounds known as triterpenoids, which are often found in plant materials, have been tested to possess nutritional and pharmaceutical activity. These plant components are referred to as nutraceuticals, and are used as ... Read more
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria

Author: Ngubane, NAC ; Gresh, L ; Ioerger, TR ; Sacchettini, JC ; Zhang, YJ ; Rubin, EJ ; Pym, A ; Khati, M Date: Nov 2013 Bacterial cell wall components have been previously used as infection biomarkers detectable by antibodies. However, it is possible that the surface of the Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), also ... Read more
Integration of IAM and GIS technologies to support decision making in the planning and procurement of physical infrastructure for the treatment of drug-resistant tuberculosis in South Africa

Author: Abbott, GR ; Parsons, SA ; Maritz, Johan ; Badenhorst, W ; De Jager, Peta Date: Oct 2008 While positive progress was being made in the latter half of last century in the treatment of the Mycobacterium tuberculosis (TB) epidemic across the world, the emergence of new drug resistant forms – multi drug-resistant TB (MDR-TB) and ... Read more
Interrogating fractionation and other sources of variability in shotgun proteomes using quality metrics

Author: Kriek, M ; Monyai, K ; Magcwebeba, TU ; Du Plessis, N ; Stoychev, SH ; Tabb, David L Date: May 2020 The increasing amount of publicly available proteomics data creates opportunities for data scientists to investigate quality metrics in novel ways. QuaMeter IDFree is used to generate quality metrics from 665 RAW files and 97 WIFF files ... Read more
Lipid containing nanodrug delivery system for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Kalombo, Lonji ; Ramalapa, B ; Jones, AT ; Swai, HS ; Verschoor, JA Date: 01 Sep 2010 Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. To improve the ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanoencapsulation of Mycolic acids as a deliverable to macrophages

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Jun 2008 The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 carbon atoms in length, ... Read more
Optical biosensing of mycobacterium tuberculosis for point-of-care diagnosis

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Hlekelele, Lerato ; Mthunzi-Kufa, Patience Date: Feb 2020 An optical biosensor is a compact analytical device formed by a bio-recognition sensing element integrated to an optical transducer system which translates a signal into a readable outcome that is measured by the detector. The target analyte ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more

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Browsing by Subject "Mycobacterium tuberculosis"

Browsing by Subject "Mycobacterium tuberculosis"

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