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Browsing by Subject "Metabolomics"

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Collision energy alteration during mass spectrometric acquisition is essential to ensure unbiased metabolomic analysis

Author: Madala, NE ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: Aug 2012 Metabolomics entails identification and quantification of all metabolites within a biological system with a given physiological status; as such, it should be unbiased. A variety of techniques are used to measure the metabolite content of ... Read more
Comparison of two GM maize varieties with a near-isogenic non-GM variety using transcriptomics, proteomics and metabolomics

Author: Barros, E ; Lezar, S ; Anttonen, MJ ; Van Dijk, JP ; Rohlig, RM ; Kok, EJ ; Engel, K-H Date: Feb 2010 The aim of this study was to evaluate the use of four nontargeted analytical methodologies in the detection of unintended effects that could be derived during genetic manipulation of crops. Three profiling technologies were used to compare ... Read more
Conversation on data mining strategies in LC-MS untargeted metabolomics: pre-processing and pre-treatment steps

Author: Tugizimana, F ; Steenkamp, Paul A ; Piater, LA ; Dubery, IA Date: Nov 2016 Untargeted metabolomic studies generate information-rich, high-dimensional, and complex datasets that remain challenging to handle and fully exploit. Despite the remarkable progress in the development of tools and algorithms, the “exhaustive” ... Read more c b
Ergosterol-induced sesquiterpenoid synthesis in tobacco Cells

Author: Tugizimana, F ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: Feb 2012 Plants have the ability to continuously respond to microbial signals in their environment. One of these stimuli is a steroid from fungal membranes, ergosterol, which does not occur in plants, but acts as a pathogen-associated molecular pattern ... Read more
Genomic Resources

Author: Barros, E ; Morris, EJ Date: 2014 The fastest growing use of maize is for the production of fuel ethanol using the enzymatic conversion of corn starch to glucose and then to ethanol as well by converting the cellulosic (non-food) parts of maize to ethanol. However for the ... Read more
Metabolomic analysis of isonitrosoacetophenone-induced perturbations in phenolic metabolism of Nicotiana tabacum cells

Author: Madala, NE ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: Oct 2013 Plants have developed biochemical and molecular responses to adapt to different stress environments. One of the characteristics of the multi-component defence response is the production of defence-related metabolites. Plant defences can be ... Read more
Metabolomic analysis of methyl jasmonate-Induced triterpenoid production in the medicinal herb Centella asiatica (L.) Urban

Author: James, TJ ; Tugizimana, F ; Steenkamp, PA ; Dubery, IA Date: Apr 2013 Centella asiatica is an important source of biologically active pentacyclic triterpenoids. The enhancement of the biosynthesis of the centellosides by manipulation of associated metabolic pathways is receiving much attention. Jasmonates play ... Read more
Metabolomics and food processing: From semolina to pasta

Author: Beleggia, R ; Platani, C ; Papa, R ; Di Chio, A ; Barros, E ; Mashaba, C ; Wirth, J ; Fammartino, A ; Sautter, C ; Conner, S ; Rauscher, J ; Stewart, D ; Cattivelli, L Date: Sep 2011 The objective of this study was to investigate the metabolite variations during industrial pasta processing (from semolina to dried pasta) for five different commercial products. Up to 76 metabolites were detected. Significant differences ... Read more
Multi-platform metabolomic analyses of ergosterol-induced dynamic changes in Nicotiana tabacum cells

Author: Tugizimana, F ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: Jan 2014 Metabolomics is providing new dimensions into understanding the intracellular adaptive responses in plants to external stimuli. In this study, a multi-technology-metabolomic approach was used to investigate the effect of the fungal sterol, ... Read more
Perturbation of pharmacologically relevant polyphenolic compounds in Moringa oleifera against photo-oxidative damages imposed by gamma radiation

Author: Ramabulana, T ; Mavunda, RD ; Steenkamp, Paul A ; Piater, LA ; Dubery, IA ; Madala, NE Date: Mar 2016 Oxidative stress is a physiological state associated with almost all biotic and abiotic stresses in plants. This phenomenon occurs due to imbalances which result from the overproduction of reactive oxygen species (ROS). Plants, however, have ... Read more
Profiling of altered metabolomic states in Nicotiana tabacum cells induced by priming agents

Author: Mhlongo, MI ; Steenkamp, Paul A ; Piater, LA ; Madala, NE ; Dubery, IA Date: Oct 2016 Metabolomics has developed into a valuable tool for advancing our understanding of plant metabolism. Plant innate immune defenses can be activated and enhanced so that, subsequent to being pre-sensitized, plants are able to launch a stronger ... Read more
The short and long of it: shorter chromatographic analysis suffice for sample classification during UHPLC-MS-based metabolic fingerprinting

Author: Madala, NE ; Tugizimana, F ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: Mar 2013 Ultra high-performance liquid chromatography hyphenated to mass spectrometry (UHPLC-MS) technologies has been widely applied in metabolomics, and the high resolution and peak capacity thereof are only some of the key aspects that are exploited ... Read more
Untargeted metabolomics analysis reveals dynamic changes in azelaic acid- and salicylic acid derivatives in LPS-treated Nicotiana tabacum cells

Author: Mhlongo, MI ; Tugizimana, F ; Piater, LA ; Steenkamp, Paul A ; Madala, NE ; Dubery, IA Date: Jan 2017 To counteract biotic stress factors, plants employ multilayered defense mechanisms responsive to pathogen-derived elicitor molecules, and regulated by different phytohormones and signaling molecules. Here, lipopolysaccharide (LPS), a ... Read more

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Browsing by Subject "Metabolomics"

Browsing by Subject "Metabolomics"

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