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Browsing by Subject "Malaria"

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Antimalarial properties of South African medicinal plants

Author: Pillay, P ; Maharaj, VJ ; Clarkson, C ; Chibale, K Date: Jan 2007 Malaria is the leading cause of death and disease worldwide. The evolution and spread of drug-resistant forms of the causative agent Plasmodium falciparum and the limited number of chemotherapeutic agents available to treat and control the ... Read more
Antiplasmodial activities in mushrooms

Author: Kadhila, NP ; Sekhoacha, M ; Tselanyane, Malefa L ; Chinsembu, KC Date: Dec 2018 This paper looked at basidiomycetes and their antiplasmodial activities from different studies. The purpose of this short review is to encourage more research on fungi in order to address major and complicated infectious diseases like malaria, ... Read more
Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore

Author: Pillay, P ; Vleggaar, R ; Maharaj, VJ ; Smith, PJ ; Lategan, CA ; Chouteau, F ; Chibale, K Date: Feb 2007 The dichloromethane extract of the leaves of Vernonia staehelinoides Harv. (Asteraceae) showed in vitro activity (IC50 ~3 µg/ml) against the chloroquine-sensitive (D10) and the chloroquine-resistant (K1) strains of Plasmodium falciparum. ... Read more
Bio-evaluation of South African plants for insecticidal properties

Author: Maharaj, R ; Gayaram, R ; Crouch, N ; Maharaj, V ; Pillay, P ; Bhagwandin, N ; Folb, PI Date: Feb 2006 Malaria is a serious health problem in South Africa affecting the lives of approximately 4 million people. Resistance to the principal vector, Anopheles arabiensis, has initiated a search for new plant-derived insecticides. Plants were selected ... Read more
Characterization and in vitro release kinetics of antimalarials from whey protein-based hydrogel biocomposites

Author: Owonubi, SJ ; Aderibigbe, BA ; Mukwevho, E ; Sadiku, ER ; Ray, Suprakas S Date: Mar 2018 In this research, hydrogel biocomposites were prepared from whey protein isolate (WPI), reduced graphene oxide (rGO), and synthetic polymers in varied ratios. Their physicochemical properties were evaluated by FTIR, SEM, TGA, AFM, and TEM. ... Read more
Climate change and environmental health in southern Africa: it's not all about malaria

Author: Wright, C ; Thambiran, Tirusha ; Matooane, M ; Engelbrecht, F ; Bopape, Mary-Jane M ; Olwach, J Date: Jul 2011 In South Africa, the most commonly talked-about climate change-related human health risk is a changing pattern in the distribution and severity of malaria. However, there are three other important issues that also deserve some attention if ... Read more
CSIR ScienceScope: Research for improved health

Author: CSIR Date: Nov 2009 In this edition of ScienceScope has chosen to focus on the CSIRs impact, and intended future impact, on health. The edition features some of the research approaches and progress in relation to the so-called diseases of poverty: malaria, ... Read more
Elucidating antimalarial drug targets/mode-of-action by application of system biology technologies

Author: Becker, J ; Mtwisha, L ; Crampton, B ; Mancama, Dalubuhle T Date: Nov 2008 Malaria is one of the world's most important tropical diseases, killing more than a million of an estimated 300-500 million infected people per annum. The species responsible for the most fatalities amongst the genus is Plasmodium falsiparum. ... Read more
Establishing malaria parasite transfection technology in South Africa.

Author: Van Brummelen, AC ; Becker, JVW ; Mancama, Dalubuhle T ; Hoppe, H Date: Jan 2010 In order to establish malaria parasite transfection technology in South Africa, firefly luciferase and green fluorescent protein (GFP) reporter constructs were prepared. In attempt to simplify these constructs, a var intron (PFC0005w), ... Read more
Haemozoin (B-haematin) biomineralization occurs by self-assembly near the lipid/water interface

Author: Egan, TJ ; Chen, JY-J ; De Villiers, KA ; Mabotha, TE ; Naidoo, KJ ; Ncokazi, KK ; Langford, SJ ; McNaughton, D ; Pandiancherri, S ; Wood, BR Date: Sep 2006 Several blood-feeding organisms, including the malaria parasite detoxify haem released from host haemoglobin by conversion to the insoluble crystalline ferriprotoporphyrin IX dimer known as haemozoin. To date the mechanism of haemozoin formation ... Read more
House modifications for preventing malaria (Review)

Author: Furnival-Adams, J ; Olanga, EA ; Napier, Mark ; Garner, P Date: Jan 2021 Despite being preventable, malaria remains an important public health problem. The World Health Organization (WHO) reports that overall progress in malaria control has plateaud for the first time since the turn of the century. Researchers and ... Read more
In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Author: Becker, JVW ; Van der Merwe, MM ; Van Brummelen, AC ; Pillay, P ; Crampton, BG ; Mmutlane, EM ; Parkinson, C ; Van Heerden, FR ; Crouch, NR ; Smith, PJ ; Mancama, Dalubuhle T ; Maharaj, VJ Date: Oct 2011 Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial ... Read more
In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa

Author: Clarkson, C ; Maharaj, VJ ; Crouch, NR ; Grace, WM ; Pillay, P ; Matsabisa, MG ; Bhagwandin, N ; Smith, PJ ; Folb, PI Date: Jun 2004 The increasing prevalence and distribution of malaria has been attributed to a number of factors, one of them being the emergence and spread of drug resistant parasites. Efforts are now being directed towards the discovery and development of ... Read more
Investigating South African plants as a source of new antimalarial drugs

Author: Pillay, P ; Maharaj, VJ ; Smith, PJ Date: Oct 2008 Based on the historical success of natural products as antimalarial drugs and the urgent need for new antimalarials, a number of South African medicinal plants have been evaluated for their antimalarial properties. This paper reviews the major ... Read more
Isolation of compounds from Sceletium tortuosum and the detection of antimalarial activity of the isolates and extracts

Author: Setshedi, I ; Peter, Xolani K ; Fouché, Gerda ; Myer, M ; Dewar, J Date: 01 Sep 2010 The genus Sceletium is classified as part of the Family Mesembryanthemaceae and belongs to the sub-family Mesembryanthemoideae. Some of the names used when referring to this genus are ‘living skeletons’ or ‘skeleton plants’ (http://ujdigisp ... Read more
Malaria incidences in South Africa linked to a climate mode in southwestern Indian Ocean

Author: Behera, SK ; Morioka, Y ; Ikeda, T ; Doi, T ; Ratnam, JV ; Nonaka, M ; Tsuzuki, A ; Imai, C ; Kim, Y ; Sweijd, Neville A Date: Sep 2018 Millions of individuals are at risk of malaria infection in sub-Saharan Africa. Compared to other highly affected countries on the continent, South Africa has an excellent record of malaria control. Nevertheless, the northeastern districts ... Read more
Molecular modelling of calcium dependent protein kinase 4 (CDPK4) from Plasmodium falciparum

Author: Tsekoa, Tsepo L Date: Oct 2009 Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ... Read more
Molecular Modelling of Calcium Dependent Protein Kinase 4 (CDPK4) from Plasmodium falciparum

Author: Tsekoa, Tsepo L ; Makungo, T ; Mancama, Dalubuhle T Date: Jul 2012 Malaria continues to be one of the most serious global health challenges. The increasing incidence of drug resistant Plasmodium strains has emphasised the need for urgent action in the development of new therapeutic strategies against this ... Read more
Nanomedicine: Recent developments and opportunities in Africa

Author: Swai, HS Date: Oct 2012 The author is the principal investigator of the TB Nano drug delivery project which is now going through pre-clinical trials with exciting results, and in this presentation the insights based on the case study will be shared. Read more
Nanomedicines for malaria chemotherapy: Encapsulation vs. polymer therapeutics

Author: Mvango, Sindisiwe ; Matshe, William MR ; Balogun, AO ; Pilcher, LA ; Balogun, Mohammed O Date: Dec 2018 Malaria is one of the oldest infectious diseases that afflict humans and its history extends back for millennia. It was once prevalent throughout the globe but today it is mainly endemic to tropical regions like sub-Saharan Africa and South-east ... Read more

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