Author:Millroy, L; London, G; Veale, R; Weinberg, M; Khati, MDate:Feb 2011Aptamers are artificial nucleic acid ligands that can be engineered to bind with high specificity to a macromolecule. Their binding specificity and small size allow for a range of therapeutic applications. One avenue of research is to develop ...Read more
Author:Alexander, Kabamba; Malatji, Kanyane; Mulaudzi, TakalaniDate:May 2020Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased ...Read more
Author:Barros, E; Nelson, SWDate:Jun 2010The aim of this study was to use conventional breeding to increase the production in maize of the human monoclonal antibody 2G12, known to have potential therapeutic properties in the prevention of HIV-1 transmission. The recombinant antibody, ...Read more
Author:Van den Berg, N; Mbobela, P; Pillay, P; London, G; Morris, L; Maharaj, V; Khati, MDate:Feb 2011A natural compound isolated from extracts of an indigenous plant in the Eastern Cape, South Africa, indicates neutralisation activity against HIV-1 pseudoviruses. This natural compound can potentially be used in a microbicide as an alternative ...Read more
Author:Van den Berg, N; Mbobela, P; Pillay, P; Maharaj, V; Khati, MDate:Jun 2011CSIR Biosciences investigated the anti-HIV properties of a plant indigenous to the Eastern Cape, commonly used by traditional healers. A natural compound isolated from the plant, coded BP36, inhibited infectivity of HIV-1 pseudoviruses. The ...Read more
Author:London, GM; Mayosi, BM; Khati, MDate:Jan 2015Aptamers, which are artificial nucleic acid ligands akin to antibodies in function, represent a new class of molecules that can prevent HIV infection. In this study, we isolated RNA aptamers against whole HV-1CAP45 enveloped pseudotyped virus, ...Read more
Author:Mufhandu, Hazel T; Madiga, M; Gray, E; Rotherham, L; Khoza, T; Morris, L; Khati, MDate:Jul 2009This paper present a chemically synthesised derivative of the B40 parental aptamer, called UCLA1 (Cohen et al., 2008), was used for neutralization of endemic subtype C clinical isolates of HIV-1 from adult and paediatric patients and subtype ...Read more
Author:Mufhandu, Hazel T; Alexandre, Kabamba B; Gray, ES; Morris, L; Khati, MDate:Sep 2016We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype ...Read more