Author:Kenyon, CP; Roth, Robyn L; Van der Westhuyzen, Christiaan W; Parkinson, CJDate:Mar 2012The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that ...Read more
Author:Kenyon, CP; Steyn, A; Roth, Robyn L; Steenkamp, PA; Nkosi, TC; Oldfield, LCDate:Jul 2011Kinase and synthetase enzymes utilise C8D-ATP in preference to non-deuterated ATP. The KIE obtained at low ATP concentrations is clearly a primary KIE demonstrating strong evidence that the bond to the isotopically substituted hydrogen is ...Read more