ResearchSpace
→
Browsing by Subject

Browsing by Subject "Biomarkers"

Now showing items 1-13 of 13

Active biomonitoring in freshwater environments: early warning signals from biomarkers in assessing biological effects of diffuse sources of pollutants

Author: Wepener, V ; Van Vuren, JHJ ; Chatiza, FP ; Mbizi, Z ; Slabbert, L ; Masola, B Date: 2005 This paper presents results from a field study in the Rietvlei Wetland system, Gauteng, South Africa using the freshwater mollusk and freshwater fish as bioindicator organisms. Active biomonitoring (ABM) exposures were conducted where organisms ... Read more
Combined silver nanoparticles and temperature effects in the Cape River crab Potamanautes perlatus - Interactions between chemical and climatic stressors

Author: Walters, Chavon R ; Cheng, Po-Hsun ; Pool, EJ ; Somerset, VS Date: Mar 2017 The influence of silver nanoparticles (AgNPs) and temperature variation on toxicity and oxidative stress responses were investigated in the tissues of the Cape River crab Potamanautes perlatus following a seven-day exposure period. Toxicity ... Read more
Ecotoxicity of silver nanomaterials in the aquatic environment: A review of literature and gaps in nano-toxicological research

Author: Walters, Chavon R ; Pool, EJ ; Somerset, VS Date: Aug 2014 There has been extensive growth in nanoscale technology in the last few decades to such a degree that nanomaterials (NMs) have become a constituent in a wide range of commercial and domestic products. With NMs already in use in several consumer ... Read more
The Lipopolysaccharide-induced metabolome signature in Arabidopsis thaliana reveals dynamic reprogramming of Phytoalexin and Phytoanticipin pathways

Author: Finnegan, T ; Steenkamp, PA ; Piater, LA ; Dubery, IA Date: 22 Sep 2016 Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to ... Read more
Lipopolysaccharide-induced metabolome signature in Arabidopsis thaliana reveals dynamic reprogramming of Phytoalexin and Phytoanticipin pathways

Author: Finnegan, T ; Steenkamp, Paul A ; Piater, LA ; Dubery, IA Date: Sep 2016 Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to ... Read more c b
Lnc-ing inflammation to disease

Author: Magagula, L ; Gagliardi, M ; Naidoo, Jerolen ; Mhlanga, Musa Date: Aug 2017 Termed 'master gene regulators' long ncRNAs (lncRNAs) have emerged as the true vanguard of the 'noncoding revolution'. Functioning at a molecular level, in most if not all cellular processes, lncRNAs exert their effects systemically. Thus, ... Read more
A look at emerging therapeutic targets for gallbladder cancer: A multi-omics approach

Author: Baichan, P ; Naicker, Previn ; Devar, J ; Smith, M ; Nweke, EE Date: Jan 2023 Gallbladder cancer (GBC) is the most frequent biliary tract cancer (including cancers of the intra- and extrahepatic biliary tree). Like many biliary tract carcinomas, GBC is identified by late diagnosis, poor prognosis, and ineffective ... Read more
Nanotoxicology: A review

Author: Walters, Chavon R ; Pool, E ; Somerset, V Date: Oct 2016 Nanotoxicology represents a new and growing research area in toxicology. It deals with the assessment of the toxicological properties of nanoparticles (NPs) with the intention of determining whether (and to what extent) they pose an environmental ... Read more
Precision medicine using drug repurposing platform - the way forward in applying novel drug combinations for Ovarian Cancer treatment

Author: Batohi, Nikayla ; Dreyer, G ; Thimiri Govindaraj, Deepak B Date: Jan 2023 More than half of the women diagnosed with ovarian cancer ultimately succumb to death after 5 years of diagnosis. Standard platinum-based chemotherapy often results in patient relapse; thus, new therapeutic strategies are required. We aim to ... Read more
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Author: Baichan, P ; Naicker, Previn ; Augustine, TN ; Smith, M ; Candy, G ; Devar, J ; Nweke, EE Date: Mar 2023 Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ... Read more
Synthesis and characterisation of quantum dots coupled to mycolic acids as a water-soluble fluorescent probe for potential lateral flow detection of antibodies and diagnosis of tuberculosis

Author: Kabwe, KP ; Nsibande, SA ; Lemmer, Yolandy ; Pilcher, LA ; Forbes, PBC Date: Nov 2021 This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ... Read more
Targeting gallbladder cancer: a pathway based perspective

Author: Baichan, P ; Naicker, Previn ; Devar, JWS ; Smith, M ; Candy, GP ; Nweke, E Date: Feb 2020 Gallbladder cancer (GBC) has a poor prognosis with a 5-year survival rate suggesting the need for more effective treatment strategies. Studying the cross-talk of several pathways involved in crucial cellular and biological processes such as ... Read more c b
Understanding the functionality of multiplexed sensors in order to aid design and enhance performance

Author: Moodley, K ; Land, K ; Muzenda, E Date: Oct 2015 The use of multiplexed paper sensors for health and environmental monitoring applications continues to rise. Multiplexed devices are capable of detecting multiple disease biomarkers or contaminants from a single sample. These devices make ... Read more

Now showing items 1-13 of 13

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Tel: + 27 12 841 2911
Email: callcentre@csir.co.za

Physical Address
Meiring Naudé Road
Brummeria
Pretoria
South Africa

Postal Address
PO Box 395
Pretoria 0001
South Africa

Social Connect

Resources on this site are free to download and reuse according to associated licensing provision. Please read the terms and conditions of usage of each resource.

Browsing by Subject "Biomarkers"

Browsing by Subject "Biomarkers"

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Social Connect