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Browsing by Subject "Biodistribution"

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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Grobler, A ; Zeevaart, JR Date: Nov 2018 The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats ... Read more
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems

Author: Semete, B ; Booysen, L ; Lemmer, Yolandy ; Kalombo, Lonji ; Katata, L ; Verschoor, J ; Swai, HS Date: Oct 2010 The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some concerns. The aim of ... Read more
Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Hayeshi, R ; Zeevaart, JR ; Ebenhan, T Date: Apr 2021 It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. ... Read more
Preclinical assessment of 68Ga-PSMA-617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Lemmer, Yolandy ; Labuschagne, Philip W ; Semete-Makokotlela, Boitumelo ; Sathekge, M ; Ebenhan, T ; Rijn Zeevaart, J Date: Jun 2019 It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable treatment regimens. ... Read more
Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles

Author: Mandiwana, V ; Kalombo, Lonji ; Venter, Karien ; Sathekge, M ; Grobler, A ; Zeevaart, JR Date: Sep 2015 Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of this study was to ... Read more

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Browsing by Subject "Biodistribution"

Browsing by Subject "Biodistribution"

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