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Antimalarial sesquiterpene lactones from oncosiphon piluliferum

Author: Pillay, P ; Maharaj, V ; Crouch, N ; Smith, P ; Lategan, C ; Vleggaar, R Date: Feb 2006 With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal ... Read more
Controlled dual release study of curcumin and a 4-aminoquinoline analog from gum acacia containing hydrogels

Author: Aderibigbe, BA ; Sadiku, ER ; Jayaramudu, J ; Ray, SS Date: Oct 2014 The potential of gum acacia containing hydrogels as controlled dual-drug delivery systems for antiprotozoal agents was investigated. 4-Aminoquinoline analog and curcumin were selected as model drugs because they exhibit antiprotozoal activity. ... Read more
Isolation of compounds from Sceletium tortuosum and the detection of antimalarial activity of the isolates and extracts

Author: Setshedi, I ; Peter, Xolani K ; Fouché, Gerda ; Myer, M ; Dewar, J Date: 01 Sep 2010 The genus Sceletium is classified as part of the Family Mesembryanthemaceae and belongs to the sub-family Mesembryanthemoideae. Some of the names used when referring to this genus are ‘living skeletons’ or ‘skeleton plants’ (http://ujdigisp ... Read more
Nanomedicines for malaria chemotherapy: Encapsulation vs. polymer therapeutics

Author: Mvango, Sindisiwe ; Matshe, William MR ; Balogun, AO ; Pilcher, LA ; Balogun, Mohammed O Date: Dec 2018 Malaria is one of the oldest infectious diseases that afflict humans and its history extends back for millennia. It was once prevalent throughout the globe but today it is mainly endemic to tropical regions like sub-Saharan Africa and South-east ... Read more
Preparation, characterization and in vitro release kinetics of polyaspartamide-based conjugates containing antimalarial and anticancer agents for combination therapy

Author: Aderibigbe, BA ; Ray, Suprakas S Date: Sep 2016 Malaria is treated by combination of two drugs in order to overcome drug resistance. Antimalarials have been found to be more effective by combining them with low doses of anticancer drugs. Polymer-drug conjugates containing aminoquinoline ... Read more
Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles

Author: Omwoyo, WN ; Ogutu, B ; Oloo, F ; Swai, H ; Kalombo, Lonji ; Melariri, P ; Mahanga, GM ; Waweru Gathirwa, JW Date: Aug 2014 Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointe ... Read more
Synthesis, characterization, and antiplasmodial activity of polymer-incorporated aminoquinolines

Author: Aderibigbe, BA ; Neuse, EW ; Sadiku, ER ; Shina Ray, S ; Smith, PJ Date: 2014 In this research, aminoquinoline compounds were synthesized, characterized and incorporated into water soluble polymers to form conjugates. The conjugates were characterized by X ray Diffraction (XRD), Thermal Gravimetric Analysis (TGA), ... Read more

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Browsing by Subject "Antimalarial"

Browsing by Subject "Antimalarial"

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