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Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity

Author: Siva Mohan Reddy, G ; Jayaramudu, J ; Sadiku, ER ; Ray, Suprakas S ; Varaprasad, K ; Aderibigbe, BA Date: 2014 The potential of soy protein isolate films as a release system for naturally occurring antiproliferative agent was investigated. The soy protein isolates was cross linked with resorcinol and the resorcinol content was varied between 10-30 %. ... Read more
A one-pot laccase-catalysed synthesis of 5,6-dihydroxylated benzo[b]furans and catechol derivatives, and their anticancer activity

Author: Wellington, Kevin W ; Qwebani-Ogunleye, T ; Kolesnikova, NI ; Brady, D ; De Koning, CB Date: Apr 2013 A commercial laccase, Suberase® from Novozymes, was used to catalyse the synthesis of 5,6-dihydroxylated benzo[b]furans and catechol derivatives. The yields were, in some cases, similar to or better than that obtained by other enzymatic, ... Read more
Polyamidoamine drug conjugates containing metal-based anticancer compounds

Author: Aderibigbe, BA ; Mugogodi, A ; Nwamadi, M ; Ray, Suprakas S ; Steenkamp, V ; Balogun, Mohammed O ; Matshe, William MR Date: Sep 2019 Polyamidoamine drug conjugates containing ferrocene and platinum analogues were prepared in this study. Fourier transform infrared spectra confirmed the successful isolation of the conjugates with signals at 3300 cm-1 for amide N–H stretch ... Read more
Preparation, characterization and in vitro release kinetics of polyaspartamide-based conjugates containing antimalarial and anticancer agents for combination therapy

Author: Aderibigbe, BA ; Ray, Suprakas S Date: Sep 2016 Malaria is treated by combination of two drugs in order to overcome drug resistance. Antimalarials have been found to be more effective by combining them with low doses of anticancer drugs. Polymer-drug conjugates containing aminoquinoline ... Read more
Synthesis and characterization of polyamidoamine conjugates of neridronic acid

Author: Aderibigbe, BA ; Sadiku, ER ; Ray, SS ; Mbianda, XY ; Fotsing, MC ; Agwuncha, SC ; Owonubi, SJ Date: Oct 2015 Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N0-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use ... Read more
Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug

Author: Ndamase, AS ; Aderibigbe, BA ; Sadiku, ER ; Labuschagne, Philip W ; Lemmer, Yolandy ; Ray, Suprakas S ; Nwamadi, M Date: Feb 2018 Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The ... Read more
Synthesis, characterization and the release kinetics of antiproliferative agents from polyamidoamine conjugates

Author: Aderibigbe, BA ; Sadiku, ER ; Ray, SS ; Mbianda, XY ; Fotsing, MC ; Jayaramudu, J ; Owonubi, SJ Date: 2015 Polyamidoamine conjugates containing curcumin and bisphosphonate were synthesized via a one-pot aqueous phase Michael addition reaction. In the design of the conjugate, bisphosphonate formed an integral part of the polymer carrier backbone. ... Read more

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Browsing by Subject "Anticancer"

Browsing by Subject "Anticancer"

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