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Browsing by Author "Zimmermann, S"

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Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus

Author: Hata, Y ; Raith, M ; Ebrahimi, SN ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj, V ; Kaiser, M ; Brun, R ; Hamburger, M Date: Apr 2013 A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovani. A CH(sub)2Cl(sub)2/MeOH (1:1) extract ... Read more
Antiprotozoal Screening of 60 South African plants, and the identification of the Antitrypanosomal Germacranolides Schkuhrin I and II

Author: Mokoka, TA ; Peter, Xolani K ; Zimmermann, S ; Hata, Y ; Adams, M ; Kaiser, M ; Moodley, N ; Maharaj, V ; Koorbanally, Nicoli A ; Hamburger, M ; Brun, B ; Fouché, Gerda Date: Aug 2013 Two hundred and seven extracts were prepared from sixty plants from South Africa and screened for in vitro activity against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. For the 21 extracts ... Read more
Antitrypanosomal isoflavan quinones from Abrus precatorius

Author: Hata, Y ; Ebrahimi, SN ; De Mieri, M ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj ; Kaiser, M ; Brun, R ; Potterat, O ; Hamburger, M Date: Mar 2014 Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu, U ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more

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Browsing by Author "Zimmermann, S"

Browsing by Author "Zimmermann, S"

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