ResearchSpace
→
Browsing by Author

Browsing by Author "Van der Westhuyzen, Christiaan W"

Now showing items 1-18 of 18

Anti-mycobacterial peroxides: A new class of agents for development against tuberculosis

Author: Van der Westhuyzen, Christiaan W ; Haynes, J ; Panayides, Jenny-Lee ; Wiid, I ; Parkinson, C Date: 2020 Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like ... Read more
Bacterial nitrilases and their regulation

Author: Chhiba, Varsha P ; Van der Westhuyzen, Christiaan W ; Bode, M ; Brady, D Date: Jun 2019 Commercially, nitrilases are valuable biocatalysts capable of converting a diverse range of nitriles to carboxylic acids for the greener synthesis of chemicals and pharmaceuticals. Nitrilases are widespread in nature and are both important ... Read more
Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Author: Bode, M ; Gledhill, Irvy MA ; Gravestock, D ; Hoppe, H ; Khan, T ; Moleele, S ; Nkabinde, L ; Pelly, S ; Van der Westhuyzen, Christiaan W Date: Sep 2010 A compound possessing anti-HIV activity similar to that of FDA-approved nevirapine was developed. It acts as a non-nucleoside reverse transcriptase inhibitor, the compound shows good cell permeability, and a quantitative structure activity ... Read more
Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

Author: Kenyon, CP ; Roth, Robyn L ; Van der Westhuyzen, Christiaan W ; Parkinson, CJ Date: Mar 2012 The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that ... Read more
Design and synthesis of a heterocyclic compound collection for probing the spatial charactistics of ATP binding sites

Author: Kenyon, CP ; Matlaba, PM ; Parkinson, CJ ; Rousseau, AL ; Van der Westhuyzen, Christiaan W Date: 28 Feb 2006 Recent years have brought about serious interest in the kinases as potential therapeutic targets in a variety of disease conditions. Much of this interest has centred around the preparation and utilisation of species which interact with the ... Read more
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Author: Theron, Anjo ; Roth, Robyn L ; Hoppe, H ; Parkinson, C ; Van der Westhuyzen, Christiaan W ; Stoychev, Stoyan H ; Wiid, I ; Pietersen, RD ; Baker, B ; Kenyon, CP Date: Oct 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase. It is considered a ... Read more
Dimethylformamide is a novel nitrilase inducer in Rhodococcus rhodochrous

Author: Chhiba, Varsha P ; Mathiba, Kgama ; Van der Westhuyzen, Christiaan W ; Steenkamp, Paul A ; Rashamuse, JK ; Stoychev, Stoyan H ; Bode, ML ; Brady, D Date: Dec 2018 Nitrilases are of commercial interest in the selective synthesis of carboxylic acids from nitriles. Nitrilase induction was achieved here in three bacterial strains through the incorporation of a previously unrecognised and inexpensive nitrilase ... Read more
Effect of substituent structure on pyrimidine electrophilic substitution

Author: Van der Westhuyzen, Christiaan W ; Rousseau, AL ; Parkinson, CJ Date: 2007 In an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these ... Read more
An efficient selective reduction of nitroarenes catalyzed by reusable silver-adsorbed waste nanocomposite

Author: Giri, S ; Das, R ; Van der Westhuyzen, Christiaan W ; Maity, Arjun Date: Jul 2017 Silver nanocomposites (AgNCs) were produced by adsorption onto an electron-rich polypyrrole-mercaptoacetic acid (PPy-MAA) composite, known to be a highly efficient adsorbent for the removal of Ag+ ions from aqueous media in the remediation ... Read more
Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

Author: Bode, ML ; Gravestock, D ; Moleele, SS ; Van der Westhuyzen, Christiaan W ; Pelly, SC ; Steenkamp, PA ; Hoppe, HC ; Khan, T ; Nkabinde, LA Date: Jun 2011 During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the ... Read more
Imidazo[1,2-a]pyridines as NNRTIs

Author: Bode, ML ; Gravestock, D ; Moleele, S ; Van der Westhuyzen, Christiaan W ; Hoppe, H ; Khan, T ; Pelly, SC Date: Jan 2010 The enzyme reverse transcriptase (RT) is a validated target for the development of anti-HIV drugs. Drugs acting against RT may act at either the catalytic site (NRTIs) or the allosteric site (NNRTIs). During random screening of a small in-house ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more
Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products

Author: Zimmermann, S ; Fouché, Gerda ; De Mieri, M ; Yukiko, Y ; Toyonobu, U ; Nthambeleni, R ; Parkinson, CJ ; Van der Westhuyzen, Christiaan W ; Kaiser, M ; Hamburger, M ; Adams, M Date: Mar 2014 Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal ... Read more
Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin

Author: Van der Westhuyzen, Christiaan W ; Parkinson, CJ Date: 2005 Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by ... Read more
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

Author: Van Greunen, DG ; Cordier, W ; Nell, M ; Van der Westhuyzen, Christiaan W ; Steenkamp, V ; Panayides, Jenny-Lee ; Riley, DL Date: Feb 2017 A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the ... Read more
Transcriptomic analysis of a Sorghum bicolor landrace identifies a role for beta-alanine betaine biosynthesis in drought tolerance

Author: Devnarain, A ; Crampton, BG ; Olivier, N ; Van der Westhuyzen, Christiaan W ; Becker, JVW ; O'Kennedy, Maretha M Date: Dec 2019 Sorghum is indigenous to Africa and a remarkably drought tolerant cereal crop. In this study, the genetic response mechanisms involved in sorghum's tolerance to progressive water deficit and re-watering were investigated in a South African ... Read more

Now showing items 1-18 of 18

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Tel: + 27 12 841 2911
Email: callcentre@csir.co.za

Physical Address
Meiring Naudé Road
Brummeria
Pretoria
South Africa

Postal Address
PO Box 395
Pretoria 0001
South Africa

Social Connect

Copyright © CSIR 2017. All Rights Reserved

Resources on this site are free to download and reuse according to associated licensing provision. Please read the terms and conditions of usage of each resource.