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Browsing by Author "Takundwa, Mutsa M"

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Application of drug repurposing-based precision medicine platform for leukaemia patient treatment

Author: Kenmogne, Vanelle L ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PN ; Thimiri Govindaraj, Deepak B Date: Oct 2022 Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
Recent advances in genome annotation and synthetic biology for the development of microbial chassis

Author: Hamese, Saltiel ; Mugwanda, Kanganwiro ; Takundwa, Mutsa M ; Prinsloo, E ; Thimiri Govindaraj, Deepak B Date: Dec 2023 This article provides an overview of microbial host selection, synthetic biology, genome annotation, metabolic modeling, and computational methods for predicting gene essentiality for developing a microbial chassis. This article focuses on ... Read more
Treatment strategies for multiple myeloma treatment and the role of high-throughput screening for precision cancer therapy

Author: Malise, TTA ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PF ; Thimiri Govindaraj, Deepak B Date: May 2023 In the past few years, development of approved drug candidates has improved the disease management of multiple myeloma (MM). However, due to drug resistance, some of the patients do not respond positively, while some of the patients acquire ... Read more

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Browsing by Author "Takundwa, Mutsa M"

Browsing by Author "Takundwa, Mutsa M"

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