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Browsing by Author "Stander, A"

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Binding pose analysis of hydroxyethylamine based ß-secretase inhibitors and application thereof to the design and synthesis of novel indeno[1,2-b]indole based inhibitors

Author: Van der Westhuizen, CJ ; Van Greunen, DG ; Cordier, W ; Nell, M ; Steenkamp, V ; Stander, A ; Panayides, Jenny-Lee ; Riley, DL Date: Nov 2020 ß-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational investigation of ... Read more
A Cytotoxic Bis(1,2,3-triazol-5-ylidene)carbazolide Gold(III) complex targets DNA by partial intercalation

Author: Van der Westhuizen, D ; Slabber, CA ; Fernandes, MA ; Joubert, DF ; Kleinhans, G ; Van der Westhuizen, Carl J ; Stander, A ; Munro, OQ ; Bezuidenhout, DI Date: Jun 2021 The syntheses of bis(triazolium)carbazole precursors and their corresponding coinage metal (Au, Ag) complexes are reported. For alkylated triazolium salts, di- or tetranuclear complexes with bridging ligands were isolated, while the bis(aryl) ... Read more
Discovery of novel Acetylcholinesterase inhibitors by virtual screening, in vitro screening, and molecular dynamics simulations

Author: Van van der Westhuizen, Johan C ; Stander, A ; Riley, DL ; Panayides, Jenny-Lee Date: Mar 2022 Alzheimer's disease is the most common neurodegenerative disease and currently poses a significant socioeconomic problem. This study describes the uses of computer-aided drug discovery techniques to identify novel inhibitors of acetylcholinesterase, ... Read more

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Browsing by Author "Stander, A"

Browsing by Author "Stander, A"

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