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Browsing by Author "Semete-Makokotlela, Boitumelo"

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In vitro characterisation of PLGA nanoparticles encapsulating rifampicin and isoniazid - Towards IVIVC

Author: Booysen, L ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, H ; Kotzé, AF Date: 01 Sep 2010 It has been postulated that antituberculosis drugs encapsulated in polymeric nanoparticles are able to control the release of these drugs in vivo. These biodegradable polymers facilitate sustained/controlled release by means of degradation ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanomedicines for the treatment of infectious diseases: Formulation, delivery and commercialization aspects

Author: Dube, A ; Semete-Makokotlela, Boitumelo ; Ramalapa, Bathabile E ; Reynolds, J ; Boury, F Date: Mar 2021 The increasing prevalence of drug resistant pathogenic strains, including multi drug resistant TB along with the growing HIV and malaria resistance demand new routes of innovation for pharmaceutical drug discovery. Nanomedicine provides the ... Read more
Permeation of PLGA nanoparticles across different in vitro models

Author: Nkabinde, LA ; Shoba-Zikhali, LN ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, HS ; Hayeshi, R ; Naicker, B ; Hillie, TK ; Hamman, JH Date: Jul 2012 Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake ... Read more
Preclinical assessment of 68Ga-PSMA-617 entrapped in a microemulsion delivery system for applications in prostate cancer PET/CT imaging

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Lemmer, Yolandy ; Labuschagne, Philip W ; Semete-Makokotlela, Boitumelo ; Sathekge, M ; Ebenhan, T ; Rijn Zeevaart, J Date: Jun 2019 It has in recent years been reported that microemulsion (ME) delivery systems provide an opportunity to improve the efficacy of a therapeutic agent whilst minimising side effects and also offer the advantage of favourable treatment regimens. ... Read more

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Browsing by Author "Semete-Makokotlela, Boitumelo"

Browsing by Author "Semete-Makokotlela, Boitumelo"

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