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Browsing by Author "Nweke, EE"

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Application of drug repurposing-based precision medicine platform for leukaemia patient treatment

Author: Kenmogne, Vanelle L ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PN ; Thimiri Govindaraj, Deepak B Date: Oct 2022 Drug resistance in leukaemia is a major problem that needs to be addressed. Precision medicine provides an avenue to reduce drug resistance through a personalised treatment plan. It has helped to better stratify patients based on their molecular ... Read more
Bioinformatics tools for gene and genome annotation analysis of microbes for synthetic biology and cancer biology applications

Author: Nweke, EE ; Suleman, Essa ; Du Plessis, M ; Thimiri Govindaraj, Deepak B Date: Aug 2021 In this book chapter, we focus on application of genome annotation and analysis of microbes for synthetic biology and cancer biology research. We particularly emphasised on application of microbial genomics in synthetic biology and cancer ... Read more
Development of insect cell line using CRISPR technology

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 In this chapter, we delineated the methods of CRISPR technology that has been used for the development of engineered insect cell line. We elaborated on how CRISPR/Cas9 genome editing in Drosophila melanogaster, Bombyx mori, Spodoptera frugiperda ... Read more
Drug sensitivity and drug repurposing platform for cancer precision medicine

Author: Nweke, EE ; Thimiri Govindaraj, Deepak B Date: Feb 2021 One of the critical Global challenges in achieving the UN Sustainable Development Goals 3 Good Health and Well Being is optimizing drug discovery and translational research for unmet medical need in both communicable and non-communicable ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
Establishment of ex vivo drug sensitivity screening platform for leukaemia and multiple myeloma using a South African patient cohort

Author: Kenmogne, VL ; Takalani, AMT ; Nweke, EE ; Takundwa, Mutsa M ; Fabian, June ; Maher, Heather ; Du Toit, Justin ; Philip-Cherian, V ; Fru, PF ; Govindaraj, DBT Date: Oct 2023 Our objective is to develop a functional precision medicine platform designed to directly identify tailored drug regimens that target individual patient cancer cells and give benefit to the same donors by supporting clinical decision-making. ... Read more
A look at emerging therapeutic targets for gallbladder cancer: A multi-omics approach

Author: Baichan, P ; Naicker, Previn ; Devar, J ; Smith, M ; Nweke, EE Date: Jan 2023 Gallbladder cancer (GBC) is the most frequent biliary tract cancer (including cancers of the intra- and extrahepatic biliary tree). Like many biliary tract carcinomas, GBC is identified by late diagnosis, poor prognosis, and ineffective ... Read more
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

Author: Baichan, P ; Naicker, Previn ; Augustine, TN ; Smith, M ; Candy, G ; Devar, J ; Nweke, EE Date: Mar 2023 Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ... Read more
SWATH-MS based proteomic profiling of Pancreatic Ductal Adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways

Author: Nweke, EE ; Naicker, Previn ; Aaron, S ; Stoychev, Stoyan J ; Tabb, DL ; Jones, OJ ; Smith, MD ; Candy, GP Date: Jun 2020 Pancreatic cancer accounts for 2.8% of new cancer cases worldwide and is projected to become by 2030 the second leading cause of cancer-related deaths. Patients of African ancestry appear to be at an increased risk for pancreatic ductal ... Read more
Treatment strategies for multiple myeloma treatment and the role of high-throughput screening for precision cancer therapy

Author: Malise, TTA ; Nweke, EE ; Takundwa, Mutsa M ; Fru, PF ; Thimiri Govindaraj, Deepak B Date: May 2023 In the past few years, development of approved drug candidates has improved the disease management of multiple myeloma (MM). However, due to drug resistance, some of the patients do not respond positively, while some of the patients acquire ... Read more

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Browsing by Author "Nweke, EE"

Browsing by Author "Nweke, EE"

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