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Browsing by Author "Nwamadi, M"

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Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

Author: Aderibigbe, BA ; Naki, T ; Steenkamp, V ; Nwamadi, M ; Ray, Suprakas S ; Balogun, Mohammed O ; Matshe, William MR Date: Sep 2019 Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome ... Read more
Polyamidoamine drug conjugates containing metal-based anticancer compounds

Author: Aderibigbe, BA ; Mugogodi, A ; Nwamadi, M ; Ray, Suprakas S ; Steenkamp, V ; Balogun, Mohammed O ; Matshe, William MR Date: Sep 2019 Polyamidoamine drug conjugates containing ferrocene and platinum analogues were prepared in this study. Fourier transform infrared spectra confirmed the successful isolation of the conjugates with signals at 3300 cm-1 for amide N–H stretch ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugaes containing dihydrofolate reductase inhibitors

Author: Aderibigbe, AB ; Mhlatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Feb 2019 Malaria is an acute disease that is caused by the protozoanPlasmodiumparasites. Drug resistance is the majorproblem that is hindering the control of this disease. In order to overcome drug resistance to commonly usedantimalarials, nanocarriers ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugates containing dihydrofolate reductase inhibitors

Author: Aderibigbe, BA ; Mhlwatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Apr 2019 Malaria is an acute disease that is caused by the protozoan Plasmodium parasites. Drug resistance is the major problem that is hindering the control of this disease. In order to overcome drug resistance to commonly used antimalarials, ... Read more
Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug

Author: Ndamase, AS ; Aderibigbe, BA ; Sadiku, ER ; Labuschagne, Philip W ; Lemmer, Yolandy ; Ray, Suprakas S ; Nwamadi, M Date: Feb 2018 Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The ... Read more

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Browsing by Author "Nwamadi, M"

Browsing by Author "Nwamadi, M"

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