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Browsing by Author "Monama, Nkwe O"

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Combined atomistic molecular calculations and experimental investigations for the architecture, screening, optimization, and characterization of pyrazinamide containing oral film formulations for tuberculosis management

Author: Adeleke, Oluwatoyin A ; Monama, Nkwe O ; Tsai, PC ; Sithole, Happy M ; Michniak-Kohn, BB Date: Dec 2015 To date, effective treatment, prophylaxis, and control of tuberculosis (TB) infection is mainly dependent on the use of drugs. However, patient noncompliance with prescribed anti-TB treatment schemes remains a major problem confronting ... Read more
Computer-aided construction and investigation of a thermodynamically stable mouth-dissolving film containing isoniazid

Author: Adeleke, Oluwatoyin A ; Karry, KM ; Michniak-Kohn, BB ; Monama, Nkwe O Date: Oct 2015 The purpose of this abstract is to design and characterize a thermodynamically stable mouth-dissolving film containing isoniazid employing in silico and in vitro techniques. Isoniazid (solubility = 140 mg/mL and log P = -0.64 at 25°C) is a ... Read more
Isoniazid-loaded orodispersible strips: Methodical design, optimization and in vitro-in silico characterization

Author: Adeleke, Oluwatoyin A ; Tsai, P ; Karry, KM ; Monama, Nkwe O ; Michniak-Kohn, BB Date: Aug 2021 Drug treatment remains the most effective global approach to managing and preventing tuberculosis. This work focuses on formulating and evaluating an optimized polyvinyl alcohol-polyethylene glycol based orodispersible strip containing ... Read more
Model inter-comparison for short-range forecasts over the southern African domain

Author: Mulovhedzi, PT ; Rambuwani, GT ; Bopape, MJ ; Maisha, R ; Monama, Nkwe O Date: Sep 2021 Numerical weather prediction (NWP) models have been increasing in skill and their capability to simulate weather systems and provide valuable information at convective scales has improved in recent years. Much effort has been put into developing ... Read more
Origin of electrochemical activity in nano-Li2MnO3; stabilization via a ‘point defect scaffold’

Author: Sayle, TXT ; Caddeo, F ; Monama, Nkwe O ; Kgatwane, KM ; Ngoepe, PE ; Sayle, DC Date: 2015 Molecular dynamics (MD) simulations of the charging of Li2MnO3 reveal that the reason nanocrystalline-Li2MnO3 is electrochemically active, in contrast to the parent bulk-Li2MnO3, is because in the nanomaterial the tunnels, in which the Li ... Read more

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Browsing by Author "Monama, Nkwe O"

Browsing by Author "Monama, Nkwe O"

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